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- W2034741330 abstract "The critical changes in the conformation of β-lactoglobulin, which expose the buried SH group and initiate sulfhydryl−disulfide interchange reactions leading to polymerization, have been studied. The initiation of sulfhydryl−disulfide interchange reaction in β-lactoglobulin occurs at 60−65 °C. Far-UV circular dichroic studies in the temperature range 25−80 °C revealed that the critical structural changes in β-lactoglobulin at 63 °C involve melting of 18−19% of β-sheet to aperiodic structure. An examination of the known crystallographic structure of β-lactoglobulin revealed that this initial event might involve melting of the E−F−G−H β-strand region of the molecule; this might expose the buried sulfhydryl group as well as one of the disulfide bonds. The reactive monomer initially forms a reactive dimer via sulfhydryl−disulfide interchange reaction with another reactive monomer. When the reactive dimer concentration reaches a critical level, it propagates a polymerization reaction. The rate of disappearance of the monomer at 63 °C follows a 1.5 kinetic order. Keywords: β-Lactoglobulin; denaturation; aggregation; conformational change; sulfhydryl−disulfide interchange; kinetics" @default.
- W2034741330 created "2016-06-24" @default.
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- W2034741330 date "1997-11-01" @default.
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- W2034741330 title "Thermal Unfolding of β-Lactoglobulin: Characterization of Initial Unfolding Events Responsible for Heat-Induced Aggregation" @default.
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- W2034741330 doi "https://doi.org/10.1021/jf970269a" @default.
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