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• W2034748879 abstract "The concept of a catheter-based strategy for managing aortic dissections and aneurysms continues to be exciting and promising. Most type B aortic dissections have initial intimal tears just beyond the left subclavian artery, and a straight graft with a side branch would be necessary to obliterate such a tear. We report the successful placement of a branched graft in a patient with type B aortic dissection. A 51-year-old woman who was believed to have acute aortic dissection was referred to our hospital on May 9, 1995. The patient's condition was managed medically because the false lumen of the descending thoracic aorta was found to be completely thrombosed by transesophageal echocardiography and contrast computed tomography. Transesophageal echocardiography during admission demonstrated that the false lumen gradually disappeared. The patient recovered favorably with medical management and was discharged from our hospital. She was readmitted, however, after reporting severe back pain on June 22, 1995. Transesophageal echocardiography revealed a large entry just beyond the left subclavian artery with reentry in the descending thoracic aorta, approximately 5 cm below the entry site. The false lumen was patent without thrombus formation. These findings were confirmed by aortography (Fig. 1) and contrast computed tomography. After a full description regarding potential complications had been given to the patient and the possibility of emergency operation had been explained to her, the patient gave informed consent for the experimental alternative of endovascular graft placement. A new graft and a delivery system were designed and developed by Inoue and colleagues.1Inoue K Htay T Kida M Fujiwara H Percutaneous implantation of aortic endovascular graft for created aneurysm: animal experiment [abstract].Circulation. 1991; 84: II421Google Scholar, 2Inoue K Htay T Long-term follow-up of percutaneously placed aortic endovascular graft: animal experiment [abstract].Circulation. 1992; 86: I636Google Scholar The graft was constructed from a Dacron polyester fabric cylinder, and the surface was supported by multiple rings of extra-flexible nickel titanium wire. The rings at both ends of the graft were covered by loosely spun Dacron polyester filaments so that the graft attached closely to the aortic wall. Two thorns made of wire, 3 to 5 mm in length, were attached at each middle ring. The thorns ensured the graft fixation by hooking into the aortic wall. The size of the tapered straight graft was 34 mm in diameter at the proximal end, 28 mm in diameter at the distal end, and 210 mm in length. The side-branch graft was 8 mm in diameter and 30 mm in length. The diameter, length, and taper were based on measurements obtained from transesophageal echocardiography, computed tomography, and magnetic resonance imaging. After initial aortography, the right femoral artery was surgically isolated and a transverse arteriotomy was performed with the patient under local anesthesia. A 22F sheath was introduced into the descending thoracic aorta over a 0.038-inch guidewire previously placed through the femoral arteriotomy under fluoroscopic guidance. The branched graft was evenly folded with loops of thread and a nickel titanium wire. The branched graft and its carrying system were introduced within the sheath and advanced to the descending thoracic aorta under fluoroscopic monitoring. During the fixing of the sheath in the descending thoracic aorta only the graft was advanced to the aortic arch. After the branched graft was positioned at the predetermined target point, the free end of a detachable wire attached to the side-branch graft was caught and pulled back by a gooseneck snare wire, which was inserted percutaneously through the left brachial artery. After the side-branch graft had been placed in the left subclavian artery, the compactly folded branched graft was deployed by removal of the nickel titanium wire, allowing rapid expansion of the branched graft by its own flexibility. Finally, the branched graft was released from the carrying system and pressed against the aortic wall by balloon inflation. Aortography was repeated to confirm that the branched graft was properly positioned and that the entry and reentry sites were completely obliterated. The arteriotomy site was subsequently repaired. The straight graft with a side-branch graft was successfully and uneventfully implanted. Immediately after the procedure, aortography showed good flow of contrast medium through the graft, with small leakage through the graft texture into the false lumen as a result of intraoperative heparinization. The patient did not require blood transfusion and was fully ambulatory after 3 days. One month after the procedure, aortography and contact computed tomography demonstrated that the false lumen had completely thrombosed, with no residual filling, and the flow through the graft was normal (Fig. 2). Although transesophageal Doppler echocardiography detected trivial patent proximal tracts communicating with the false lumen, the false lumen had almost completely thrombosed. Various types of grafts and stents have been developed since 1969, when Dotter3Dotter CT Transluminally-placed coilspring endoarterial tube grafts: long-term patency in canine popliteal artery.Invest Radiol. 1969; 4: 329-332Crossref PubMed Scopus (532) Google Scholar initially inserted stainless steel coils as a vascular stent in canine popliteal arteries. Clinical endovascular placement of straight stent grafts for the treatment of aortic dissection has already been reported,4Dake MD Miller DC Semba CP Mitchell RS Walker PJ Liddell RP Transluminal placement of endovascular stent-grafts for the treatment of descending thoracic aortic aneurysms.N Engl J Med. 1994; 331: 1729-1734Crossref PubMed Scopus (1303) Google Scholar but placement of these stent grafts was limited to sites that did not include the origin of the major aortic arterial branches. With the branched graft, we succeeded in endovascular repair of type B dissection with intimal tear just beyond the left subclavian artery. If long-term results are favorable, endovascular repair of larger dissections in patients with type B dissection would be possible. Careful long-term evaluation and further improvement in devices and techniques will, however, be necessary for extensive clinical use." @default.
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• W2034748879 title "Clinical endovascular placement of branched graft for type B aortic dissection" @default.
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