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- W2034749061 abstract "A segment of fresh rabbit thoracic aorta (RbA) was turned inside out and superfused (1.5 ml/min) with citrated (3.8%) or heparinized (10 U/ml) blood of rabbit and the superfusate was discarded. RbA gained in weight due to deposition of thrombi on its endothelial surface. These thrombi were mainly composed of platelets. The interaction between platelets and endothelium was augmented in RbAs from animals with atherosclerosis and in RbAs pretreated with aspirin (110 μM) or 15-HPETE (150 μM) or by the enzymatic system generating oxygen free radicals (xanthine: xanthine oxidase - 100 μM : 0.1 U/ml). On the other hand, this interaction was impaired by superoxide dismutase (20 U/ml) or catalase (0.2 U/ml). Finally, the dissipation of thrombi by thromboxane A2-synthetase inhibitor - dazoxiben was found to be related to an increase in endothelial generation of prostacyclin." @default.
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- W2034749061 date "1990-02-01" @default.
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- W2034749061 title "A biological method for studying the interaction between platelets and vascular endothelium" @default.
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- W2034749061 doi "https://doi.org/10.1016/0049-3848(90)90252-8" @default.
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