FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034750980> ?p ?o ?g. }

• W2034750980 abstract "Glitazones are known to modulate fatty acid-induced effects on insulin secretion in the pancreatic beta-cell. The present study focused on combined effects of troglitazone and oleate on preproinsulin (PPI) biosynthesis. Insulin-producing INS-1 cells were incubated for 4 hr at 11.2mM glucose in the presence (O(+)) or absence (O(-)) of 200 microM oleate with (T(+)) or without (T(-)) 10 microM troglitazone. After cell lysis, cytoplasmic RNA was extracted and employed for Northern blotting and corresponding in vitro translation. Compared with untreated controls (CTRL=O(-)/T(-)), the cellular content of PPI-mRNA from cells which had been simultaneously treated by troglitazone and oleate (O(+)/T(+)) was significantly diminished (O(+)/T(+)=75+/-10% x CTRL; P=0.015). The PPI-mRNA content from those cells which had been exclusively exposed either to oleate (O(+)/T(-)) or troglitazone (O(-)/T(+)) did not significantly differ from that of the untreated controls. In spite of that decreased PPI-mRNA content, in vitro translation revealed the highest yield of newly synthesized PPI in RNA samples from those cells which had been simultaneously exposed to oleate and troglitazone before (O(+)/T(+)=1.6+/-0.3 x CTRL; P=0.01). It is concluded that troglitazone and oleate synergistically affect the translational rate at the level of the PPI-mRNA molecule." @default.
• W2034750980 created "2016-06-24" @default.
• W2034750980 creator A5033273594 @default.
• W2034750980 creator A5036195478 @default.
• W2034750980 creator A5038969730 @default.
• W2034750980 creator A5040456004 @default.
• W2034750980 creator A5067303896 @default.
• W2034750980 creator A5075483636 @default.
• W2034750980 creator A5085788744 @default.
• W2034750980 date "2002-12-01" @default.
• W2034750980 modified "2023-09-27" @default.
• W2034750980 title "Synergistic effects of troglitazone and oleate on the translatability of preproinsulin mRNA from INS-1 cells" @default.
• W2034750980 cites W1535097706 @default.
• W2034750980 cites W1567054765 @default.
• W2034750980 cites W1643947316 @default.
• W2034750980 cites W1870996486 @default.
• W2034750980 cites W1913952392 @default.
• W2034750980 cites W1965520579 @default.
• W2034750980 cites W1969347353 @default.
• W2034750980 cites W1977195879 @default.
• W2034750980 cites W1997520810 @default.
• W2034750980 cites W1999513011 @default.
• W2034750980 cites W1999783492 @default.
• W2034750980 cites W2002711503 @default.
• W2034750980 cites W2004944131 @default.
• W2034750980 cites W2009020353 @default.
• W2034750980 cites W2011419421 @default.
• W2034750980 cites W2014036948 @default.
• W2034750980 cites W2015910179 @default.
• W2034750980 cites W2017783641 @default.
• W2034750980 cites W2019570781 @default.
• W2034750980 cites W2020468088 @default.
• W2034750980 cites W2020546688 @default.
• W2034750980 cites W2021286587 @default.
• W2034750980 cites W2029410945 @default.
• W2034750980 cites W2029491503 @default.
• W2034750980 cites W2031898359 @default.
• W2034750980 cites W2036344921 @default.
• W2034750980 cites W2036848107 @default.
• W2034750980 cites W2036873907 @default.
• W2034750980 cites W2051055391 @default.
• W2034750980 cites W2051770908 @default.
• W2034750980 cites W2052311839 @default.
• W2034750980 cites W2063720970 @default.
• W2034750980 cites W2067165167 @default.
• W2034750980 cites W2068531968 @default.
• W2034750980 cites W2085588685 @default.
• W2034750980 cites W2087061260 @default.
• W2034750980 cites W2089162704 @default.
• W2034750980 cites W2090527653 @default.
• W2034750980 cites W2091035564 @default.
• W2034750980 cites W2092342311 @default.
• W2034750980 cites W2093908424 @default.
• W2034750980 cites W2099939845 @default.
• W2034750980 cites W2105072053 @default.
• W2034750980 cites W2108709856 @default.
• W2034750980 cites W2124081028 @default.
• W2034750980 cites W2153973987 @default.
• W2034750980 cites W2158031822 @default.
• W2034750980 cites W2169421904 @default.
• W2034750980 cites W2323984091 @default.
• W2034750980 cites W3192686273 @default.
• W2034750980 doi "https://doi.org/10.1016/s0006-2952(02)01352-7" @default.
• W2034750980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12429352" @default.
• W2034750980 hasPublicationYear "2002" @default.
• W2034750980 type Work @default.
• W2034750980 sameAs 2034750980 @default.
• W2034750980 citedByCount "6" @default.
• W2034750980 crossrefType "journal-article" @default.
• W2034750980 hasAuthorship W2034750980A5033273594 @default.
• W2034750980 hasAuthorship W2034750980A5036195478 @default.
• W2034750980 hasAuthorship W2034750980A5038969730 @default.
• W2034750980 hasAuthorship W2034750980A5040456004 @default.
• W2034750980 hasAuthorship W2034750980A5067303896 @default.
• W2034750980 hasAuthorship W2034750980A5075483636 @default.
• W2034750980 hasAuthorship W2034750980A5085788744 @default.
• W2034750980 hasConcept C104317684 @default.
• W2034750980 hasConcept C105580179 @default.
• W2034750980 hasConcept C126322002 @default.
• W2034750980 hasConcept C127078168 @default.
• W2034750980 hasConcept C134018914 @default.
• W2034750980 hasConcept C185592680 @default.
• W2034750980 hasConcept C202751555 @default.
• W2034750980 hasConcept C2778150266 @default.
• W2034750980 hasConcept C2779306644 @default.
• W2034750980 hasConcept C55493867 @default.
• W2034750980 hasConcept C71924100 @default.
• W2034750980 hasConcept C86803240 @default.
• W2034750980 hasConceptScore W2034750980C104317684 @default.
• W2034750980 hasConceptScore W2034750980C105580179 @default.
• W2034750980 hasConceptScore W2034750980C126322002 @default.
• W2034750980 hasConceptScore W2034750980C127078168 @default.
• W2034750980 hasConceptScore W2034750980C134018914 @default.
• W2034750980 hasConceptScore W2034750980C185592680 @default.
• W2034750980 hasConceptScore W2034750980C202751555 @default.
• W2034750980 hasConceptScore W2034750980C2778150266 @default.
• W2034750980 hasConceptScore W2034750980C2779306644 @default.
• W2034750980 hasConceptScore W2034750980C55493867 @default.
• W2034750980 hasConceptScore W2034750980C71924100 @default.
• W2034750980 hasConceptScore W2034750980C86803240 @default.

• next