Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034750982> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2034750982 endingPage "821" @default.
- W2034750982 startingPage "815" @default.
- W2034750982 abstract "Background. Hyperoxic reperfusion from global ischemia worsens functional outcome because of oxygen radical-mediated injury. This study tested the hypothesis that hyperoxic reperfusion would exacerbate postischemic renal dysfunction. Methods. Twenty-nine healthy, uninephrectomized, male mongrel rabbits (Oryctolagus cuniculus) in 3 groups were subjected to 30 minutes of complete normothermic renal ischemia followed by reperfusion under hyperoxic or normoxic conditions. The groups were: hyperoxically reperfused (n = 8), normoxically reperfused (n = 8), hyperoxic sham (no ischemia, n = 5), and allopurinol-pretreated (50 mg/kg, intravenously), hyperoxically reperfused animals (n = 8). Plasma concentrations of creatinine, urea nitrogen and electrolytes were measured at 0, 24, 48, and 72 hours after ischemia and served as functional outcome markers. Histopathologic analysis of kidneys for injury was performed by an expert who was blinded to the procedures. Results. Plasma creatinine in hyperoxically reperfused rabbits was significantly elevated above normoxic (P =.02) and sham (P =.003) animals by 48 hours and remained elevated to 72 hours. Plasma urea nitrogen in hyperoxically reperfused rabbits was significantly elevated above the normoxic group (P =.01), the sham group (P =.02), and the allopurinol group (P =.04) by 72 hours. These coincided with a significantly elevated histopathologic injury score in hyperoxically reperfused rabbits compared with sham (P =.019), normoxic (P =.035), and allopurinol-pretreated hyperoxically reperfused animals (P =.037). Conclusions. Hyperoxic reperfusion exacerbates renal dysfunction after 30 minutes of complete normothermic ischemia. This dysfunction may be mediated by oxygen radical-related injury. (Surgery 2000;128:815-21.)" @default.
- W2034750982 created "2016-06-24" @default.
- W2034750982 creator A5013159737 @default.
- W2034750982 creator A5017090204 @default.
- W2034750982 creator A5031696528 @default.
- W2034750982 creator A5041307784 @default.
- W2034750982 creator A5059704175 @default.
- W2034750982 creator A5067131482 @default.
- W2034750982 date "2000-11-01" @default.
- W2034750982 modified "2023-10-01" @default.
- W2034750982 title "Hyperoxic reperfusion exacerbates postischemic renal dysfunction" @default.
- W2034750982 cites W1551206527 @default.
- W2034750982 cites W1990437328 @default.
- W2034750982 cites W2045094436 @default.
- W2034750982 cites W2049191252 @default.
- W2034750982 cites W2065842089 @default.
- W2034750982 cites W2076495832 @default.
- W2034750982 cites W2078617905 @default.
- W2034750982 cites W2091381725 @default.
- W2034750982 cites W2154378961 @default.
- W2034750982 cites W2788894779 @default.
- W2034750982 cites W4301764139 @default.
- W2034750982 doi "https://doi.org/10.1067/msy.2000.109117" @default.
- W2034750982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11056445" @default.
- W2034750982 hasPublicationYear "2000" @default.
- W2034750982 type Work @default.
- W2034750982 sameAs 2034750982 @default.
- W2034750982 citedByCount "30" @default.
- W2034750982 countsByYear W20347509822012 @default.
- W2034750982 countsByYear W20347509822013 @default.
- W2034750982 countsByYear W20347509822014 @default.
- W2034750982 countsByYear W20347509822015 @default.
- W2034750982 countsByYear W20347509822019 @default.
- W2034750982 countsByYear W20347509822021 @default.
- W2034750982 countsByYear W20347509822022 @default.
- W2034750982 countsByYear W20347509822023 @default.
- W2034750982 crossrefType "journal-article" @default.
- W2034750982 hasAuthorship W2034750982A5013159737 @default.
- W2034750982 hasAuthorship W2034750982A5017090204 @default.
- W2034750982 hasAuthorship W2034750982A5031696528 @default.
- W2034750982 hasAuthorship W2034750982A5041307784 @default.
- W2034750982 hasAuthorship W2034750982A5059704175 @default.
- W2034750982 hasAuthorship W2034750982A5067131482 @default.
- W2034750982 hasConcept C126322002 @default.
- W2034750982 hasConcept C126894567 @default.
- W2034750982 hasConcept C2778176769 @default.
- W2034750982 hasConcept C2780114680 @default.
- W2034750982 hasConcept C2780261098 @default.
- W2034750982 hasConcept C2780306776 @default.
- W2034750982 hasConcept C2780721119 @default.
- W2034750982 hasConcept C42219234 @default.
- W2034750982 hasConcept C541997718 @default.
- W2034750982 hasConcept C71924100 @default.
- W2034750982 hasConceptScore W2034750982C126322002 @default.
- W2034750982 hasConceptScore W2034750982C126894567 @default.
- W2034750982 hasConceptScore W2034750982C2778176769 @default.
- W2034750982 hasConceptScore W2034750982C2780114680 @default.
- W2034750982 hasConceptScore W2034750982C2780261098 @default.
- W2034750982 hasConceptScore W2034750982C2780306776 @default.
- W2034750982 hasConceptScore W2034750982C2780721119 @default.
- W2034750982 hasConceptScore W2034750982C42219234 @default.
- W2034750982 hasConceptScore W2034750982C541997718 @default.
- W2034750982 hasConceptScore W2034750982C71924100 @default.
- W2034750982 hasIssue "5" @default.
- W2034750982 hasLocation W20347509821 @default.
- W2034750982 hasLocation W20347509822 @default.
- W2034750982 hasOpenAccess W2034750982 @default.
- W2034750982 hasPrimaryLocation W20347509821 @default.
- W2034750982 hasRelatedWork W2068335228 @default.
- W2034750982 hasRelatedWork W2076649548 @default.
- W2034750982 hasRelatedWork W2141151143 @default.
- W2034750982 hasRelatedWork W2367367573 @default.
- W2034750982 hasRelatedWork W2369633584 @default.
- W2034750982 hasRelatedWork W2382229649 @default.
- W2034750982 hasRelatedWork W2382466601 @default.
- W2034750982 hasRelatedWork W2390847726 @default.
- W2034750982 hasRelatedWork W2392407100 @default.
- W2034750982 hasRelatedWork W2466635866 @default.
- W2034750982 hasVolume "128" @default.
- W2034750982 isParatext "false" @default.
- W2034750982 isRetracted "false" @default.
- W2034750982 magId "2034750982" @default.
- W2034750982 workType "article" @default.