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- W2034751554 endingPage "25" @default.
- W2034751554 startingPage "15" @default.
- W2034751554 abstract "Conventional anticancer chemotherapy has been historically thought to act through direct killing of tumor cells. This concept stems from the fact that cytotoxic drugs interfere with DNA synthesis and replication. Accumulating evidence, however, indicates that the antitumor activities of chemotherapy also rely on several off-target effects, especially directed to the host immune system, that cooperate for successful tumor eradication. Chemotherapeutic agents stimulate both the innate and adaptive arms of the immune system through several modalities: (i) by promoting specific rearrangements on dying tumor cells, which render them visible to the immune system; (ii) by influencing the homeostasis of the hematopoietic compartment through transient lymphodepletion followed by rebound replenishment of immune cell pools; (iii) by subverting tumor-induced immunosuppressive mechanisms and (iv) by exerting direct or indirect stimulatory effects on immune effectors. Among the indirect ways of immune cell stimulation, some cytotoxic drugs have been shown to induce an immunogenic type of cell death in tumor cells, resulting in the emission of specific signals that trigger phagocytosis of cell debris and promote the maturation of dendritic cells, ultimately resulting in the induction of potent antitumor responses. Here, we provide an extensive overview of the multiple immune-based mechanisms exploited by the most commonly employed cytotoxic drugs, with the final aim of identifying prerequisites for optimal combination with immunotherapy strategies for the development of more effective treatments against cancer." @default.
- W2034751554 created "2016-06-24" @default.
- W2034751554 creator A5009678390 @default.
- W2034751554 creator A5025265080 @default.
- W2034751554 creator A5055337724 @default.
- W2034751554 creator A5065469646 @default.
- W2034751554 date "2013-06-21" @default.
- W2034751554 modified "2023-10-17" @default.
- W2034751554 title "Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer" @default.
- W2034751554 cites W1229824604 @default.
- W2034751554 cites W1486665165 @default.
- W2034751554 cites W1542537947 @default.
- W2034751554 cites W1555615616 @default.
- W2034751554 cites W1565732077 @default.
- W2034751554 cites W1566335138 @default.
- W2034751554 cites W1584005881 @default.
- W2034751554 cites W1933156295 @default.
- W2034751554 cites W1967367784 @default.
- W2034751554 cites W1969464492 @default.
- W2034751554 cites W1971754021 @default.
- W2034751554 cites W1973091654 @default.
- W2034751554 cites W1979235929 @default.
- W2034751554 cites W1980980429 @default.
- W2034751554 cites W1982696984 @default.
- W2034751554 cites W1983923482 @default.
- W2034751554 cites W1984133971 @default.
- W2034751554 cites W1987446429 @default.
- W2034751554 cites W1989574516 @default.
- W2034751554 cites W1992416250 @default.
- W2034751554 cites W1992773898 @default.
- W2034751554 cites W1993442154 @default.
- W2034751554 cites W1994587515 @default.
- W2034751554 cites W1996385848 @default.
- W2034751554 cites W1997683123 @default.
- W2034751554 cites W1998074965 @default.
- W2034751554 cites W1999132647 @default.
- W2034751554 cites W1999998145 @default.
- W2034751554 cites W2000884139 @default.
- W2034751554 cites W2002409863 @default.
- W2034751554 cites W2007539452 @default.
- W2034751554 cites W2008365194 @default.
- W2034751554 cites W2008512592 @default.
- W2034751554 cites W2011882121 @default.
- W2034751554 cites W2013492504 @default.
- W2034751554 cites W2020744745 @default.
- W2034751554 cites W2023283620 @default.
- W2034751554 cites W2023517900 @default.
- W2034751554 cites W2023843355 @default.
- W2034751554 cites W2024049166 @default.
- W2034751554 cites W2024711409 @default.
- W2034751554 cites W2025115481 @default.
- W2034751554 cites W2025591320 @default.
- W2034751554 cites W2026143081 @default.
- W2034751554 cites W2032724602 @default.
- W2034751554 cites W2033691664 @default.
- W2034751554 cites W2033708244 @default.
- W2034751554 cites W2033880174 @default.
- W2034751554 cites W2034332201 @default.
- W2034751554 cites W2038218697 @default.
- W2034751554 cites W2038918212 @default.
- W2034751554 cites W2041221416 @default.
- W2034751554 cites W2041281561 @default.
- W2034751554 cites W2044253211 @default.
- W2034751554 cites W2046036434 @default.
- W2034751554 cites W2049740505 @default.
- W2034751554 cites W2051122657 @default.
- W2034751554 cites W2052874737 @default.
- W2034751554 cites W2052914449 @default.
- W2034751554 cites W2056255115 @default.
- W2034751554 cites W2056893124 @default.
- W2034751554 cites W2057329715 @default.
- W2034751554 cites W2059409197 @default.
- W2034751554 cites W2060411131 @default.
- W2034751554 cites W2060672294 @default.
- W2034751554 cites W2064058305 @default.
- W2034751554 cites W2064084286 @default.
- W2034751554 cites W2065136791 @default.
- W2034751554 cites W2065930081 @default.
- W2034751554 cites W2066518904 @default.
- W2034751554 cites W2069500071 @default.
- W2034751554 cites W2070805690 @default.
- W2034751554 cites W2078448383 @default.
- W2034751554 cites W2078492832 @default.
- W2034751554 cites W2078784857 @default.
- W2034751554 cites W2079068389 @default.
- W2034751554 cites W2083626303 @default.
- W2034751554 cites W2086962524 @default.
- W2034751554 cites W2087354330 @default.
- W2034751554 cites W2088412732 @default.
- W2034751554 cites W2088765739 @default.
- W2034751554 cites W2089828715 @default.
- W2034751554 cites W2091103707 @default.
- W2034751554 cites W2091123006 @default.
- W2034751554 cites W2093424661 @default.
- W2034751554 cites W2094955298 @default.
- W2034751554 cites W2095359278 @default.
- W2034751554 cites W2097894274 @default.
- W2034751554 cites W2097995306 @default.