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- W2034752328 abstract "A total of 297 resected Japanese non-small cell lung cancers (74 squamous cell carcinomas and 223 adenocarcinomas) were analyzed to evaluate the validity of the p53 mutation spectrum as a fingerprint for mutagenic substances as etiological factors. Frequencies of G→T transversions in smokers were significantly higher than in non-smokers (P = 0.003) and the average incidence of G→T at hot spot codons of adduct formation was higher than that in other codons in smokers and in the hot spots in non-smokers. Further, the mutation showed a marked strand bias. G→A transitions at CpG sites (CpG→CpA) were equally distributed in smokers and non-smokers, and on both strands. A→G transitions did not show any variation with smoking status in terms of frequency, but exhibited a marked strand bias. Taken together, the G→T may be a fingerprint of direct mutagenic action of tobacco-related compounds, the A→G being a new marker for other environmental chemicals, while the CpG→CpA may be attributable to endogenous spontaneous mutation, for active in lung carcinogenesis. (Cancer Sci 2008; 99: 287–295)" @default.
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- W2034752328 date "2008-02-01" @default.
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- W2034752328 title "Etiologic value of p53 mutation spectra and differences with histology in lung cancers" @default.
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- W2034752328 doi "https://doi.org/10.1111/j.1349-7006.2007.00686.x" @default.
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