FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034753008> ?p ?o ?g. }

• W2034753008 endingPage "867" @default.
• W2034753008 startingPage "861" @default.
• W2034753008 abstract "Background Cystic fibrosis (CF) is caused by a defect in cystic fibrosis transmembrane conductance regulator (CFTR) activity, often resulting in an incurable airway disease. Gene therapy into the conducting airway epithelium is a potential cure for CF; however, most gene vectors do not result in long-lived expression, and require re-dosing. Perversely, intrinsic host immune responses can then block renewed gene transfer. Methods To investigate whether persistent gene expression could be achieved after a single dosing event, thus avoiding the issue of blocking host responses, we used a gene transfer protocol that combined an airway pretreatment using lysophosphatidylcholine with a human immunodeficiency virus type-1 (vesicular stomatitis virus G pseudotype) derived lentiviral vector to test whether an integrating vector could produce gene expression able to last for a substantial part of the lifetime of the laboratory mouse. Results We found that a single dose of LV-LacZ produced immediate as well as lifetime mouse airway expression, confirming our hypothesis that use of an integrating vector extends transgene expression. Importantly, LV-CFTR dosing achieved at least 12 months of CFTR expression, representing partial functional correction of the CFTR defect in CF-null mice. Conclusions These findings validate the potential of this methodology for developing a gene transfer treatment for CF airway disease. Copyright © 2009 John Wiley & Sons, Ltd." @default.
• W2034753008 created "2016-06-24" @default.
• W2034753008 creator A5011387086 @default.
• W2034753008 creator A5036025624 @default.
• W2034753008 creator A5082116093 @default.
• W2034753008 creator A5088076449 @default.
• W2034753008 creator A5088505289 @default.
• W2034753008 creator A5088712802 @default.
• W2034753008 date "2009-10-01" @default.
• W2034753008 modified "2023-09-26" @default.
• W2034753008 title "Single-dose lentiviral gene transfer for lifetime airway gene expression" @default.
• W2034753008 cites W1854757022 @default.
• W2034753008 cites W1968400553 @default.
• W2034753008 cites W1973735945 @default.
• W2034753008 cites W1977054730 @default.
• W2034753008 cites W1977911448 @default.
• W2034753008 cites W1991519731 @default.
• W2034753008 cites W1992287618 @default.
• W2034753008 cites W2008188840 @default.
• W2034753008 cites W2010388612 @default.
• W2034753008 cites W2016149094 @default.
• W2034753008 cites W2041706988 @default.
• W2034753008 cites W2048324572 @default.
• W2034753008 cites W2049340874 @default.
• W2034753008 cites W2057714065 @default.
• W2034753008 cites W2057879405 @default.
• W2034753008 cites W2061452259 @default.
• W2034753008 cites W2072771134 @default.
• W2034753008 cites W2077658669 @default.
• W2034753008 cites W2078051637 @default.
• W2034753008 cites W2096762000 @default.
• W2034753008 cites W2108047993 @default.
• W2034753008 cites W2112811972 @default.
• W2034753008 cites W2113402490 @default.
• W2034753008 cites W2122868566 @default.
• W2034753008 cites W2132073283 @default.
• W2034753008 cites W2140407450 @default.
• W2034753008 cites W2145604558 @default.
• W2034753008 cites W2148019580 @default.
• W2034753008 cites W2163894456 @default.
• W2034753008 cites W4249370425 @default.
• W2034753008 doi "https://doi.org/10.1002/jgm.1368" @default.
• W2034753008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19634193" @default.
• W2034753008 hasPublicationYear "2009" @default.
• W2034753008 type Work @default.
• W2034753008 sameAs 2034753008 @default.
• W2034753008 citedByCount "66" @default.
• W2034753008 countsByYear W20347530082012 @default.
• W2034753008 countsByYear W20347530082013 @default.
• W2034753008 countsByYear W20347530082014 @default.
• W2034753008 countsByYear W20347530082015 @default.
• W2034753008 countsByYear W20347530082016 @default.
• W2034753008 countsByYear W20347530082017 @default.
• W2034753008 countsByYear W20347530082018 @default.
• W2034753008 countsByYear W20347530082019 @default.
• W2034753008 countsByYear W20347530082020 @default.
• W2034753008 countsByYear W20347530082021 @default.
• W2034753008 countsByYear W20347530082022 @default.
• W2034753008 countsByYear W20347530082023 @default.
• W2034753008 crossrefType "journal-article" @default.
• W2034753008 hasAuthorship W2034753008A5011387086 @default.
• W2034753008 hasAuthorship W2034753008A5036025624 @default.
• W2034753008 hasAuthorship W2034753008A5082116093 @default.
• W2034753008 hasAuthorship W2034753008A5088076449 @default.
• W2034753008 hasAuthorship W2034753008A5088505289 @default.
• W2034753008 hasAuthorship W2034753008A5088712802 @default.
• W2034753008 hasConcept C102230213 @default.
• W2034753008 hasConcept C104317684 @default.
• W2034753008 hasConcept C111599444 @default.
• W2034753008 hasConcept C135983454 @default.
• W2034753008 hasConcept C150194340 @default.
• W2034753008 hasConcept C203014093 @default.
• W2034753008 hasConcept C2776938444 @default.
• W2034753008 hasConcept C2778428886 @default.
• W2034753008 hasConcept C32470452 @default.
• W2034753008 hasConcept C40767141 @default.
• W2034753008 hasConcept C54355233 @default.
• W2034753008 hasConcept C86803240 @default.
• W2034753008 hasConcept C92087593 @default.
• W2034753008 hasConceptScore W2034753008C102230213 @default.
• W2034753008 hasConceptScore W2034753008C104317684 @default.
• W2034753008 hasConceptScore W2034753008C111599444 @default.
• W2034753008 hasConceptScore W2034753008C135983454 @default.
• W2034753008 hasConceptScore W2034753008C150194340 @default.
• W2034753008 hasConceptScore W2034753008C203014093 @default.
• W2034753008 hasConceptScore W2034753008C2776938444 @default.
• W2034753008 hasConceptScore W2034753008C2778428886 @default.
• W2034753008 hasConceptScore W2034753008C32470452 @default.
• W2034753008 hasConceptScore W2034753008C40767141 @default.
• W2034753008 hasConceptScore W2034753008C54355233 @default.
• W2034753008 hasConceptScore W2034753008C86803240 @default.
• W2034753008 hasConceptScore W2034753008C92087593 @default.
• W2034753008 hasIssue "10" @default.
• W2034753008 hasLocation W20347530081 @default.
• W2034753008 hasLocation W20347530082 @default.
• W2034753008 hasOpenAccess W2034753008 @default.
• W2034753008 hasPrimaryLocation W20347530081 @default.
• W2034753008 hasRelatedWork W1981933257 @default.

• next