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- W2034755253 abstract "In the late 1970s a profound and consistent loss of choline acetyl transferase (CT), a presynaptic marker for acetylcholine (ACh), was observed in the brains of Alzheimer disease (AD) patients when compared to age-matched controls (see Bowen, 1983; Perry and Perry, 1980). A correlation was then reported between these. Such post mortem changes were correlated with the degree of clinical dementia measured premortem (Bartus et al., 1982). Losses in ACh receptor density in the cerebral cortex and hippocampus in AD patients correlated with the degree of intellectual impairment (Lehericy et al., 1993; Terry et al., 1991). These receptor losses were predominantly to presynaptic receptors with little or no change in the number of postsynaptic receptors (Mash, 1985)." @default.
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- W2034755253 date "1996-06-01" @default.
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- W2034755253 title "Muscarinic partial agonists in the symptomatic treatment of Alzheimer's Disease" @default.
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- W2034755253 doi "https://doi.org/10.1016/0924-977x(96)87436-0" @default.
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