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• W2034756128 abstract "Abstract Background In the genome of Caenorhabditis elegans , homopolymeric poly-G/poly-C tracts (G/C tracts) exist at high frequency and are maintained by the activity of the DOG-1 protein. The frequency and distribution of G/C tracts in the genomes of C. elegans and the related nematode, C. briggsae were analyzed to investigate possible biological roles for G/C tracts. Results In C. elegans , G/C tracts are distributed along every chromosome in a non-random pattern. Most G/C tracts are within introns or are close to genes. Analysis of SAGE data showed that G/C tracts correlate with the levels of regional gene expression in C. elegans . G/C tracts are over-represented and dispersed across all chromosomes in another Caenorhabditis species, C. briggsae . However, the positions and distribution of G/C tracts in C. briggsae differ from those in C. elegans . Furthermore, the C. briggsae dog-1 ortholog CBG19723 can rescue the mutator phenotype of C. elegans dog-1 mutants. Conclusion The abundance and genomic distribution of G/C tracts in C. elegans , the effect of G/C tracts on regional transcription levels, and the lack of positional conservation of G/C tracts in C. briggsae suggest a role for G/C tracts in chromatin structure but not in the transcriptional regulation of specific genes." @default.
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• W2034756128 date "2007-11-07" @default.
• W2034756128 modified "2023-10-07" @default.
• W2034756128 title "Poly-G/poly-C tracts in the genomes of Caenorhabditis" @default.
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• W2034756128 doi "https://doi.org/10.1186/1471-2164-8-403" @default.
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