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- W2034756284 abstract "A purified myo-inositol-deficient balanced diet containing phthalylsulfathiazole and hydrogenated cotton-seed oil produced myo-inositol responsive lipodystrophy in rats in a short period of time without interfering with their growth. The deficient rats, compared to the control rats, had increased levels of triacylglycerols in the liver (2.6- and 5.3-fold higher for one and two weeks of treatment), a concomitant increase in the non-esterified fatty acid levels in the serum and raised levels of cholesterol in the liver. The alteration of lipid levels developed by the deficient diet was rectified completely by an administration of myo-inositol and partially by an administration of essential fatty acids.Gas-chromatographic analysis of the liver lipids showed that in the myo-inositol-deficient rats, the palmitic, palmitoleic and oleic acids increased significantly, while a significant decrease was noted in the levels of stearic, linoleic and arachidonic acids both in the triacylglycerol fraction and in the total liver lipids. However, myo-inositol deficiency did not produce a corresponding effect in the liver phospholipid fraction. Calculation of the weight distribution of fatty acids has revealed that an increase in the level of triglycerides in the deficient rats is caused mainly by an increase in the levels of palmitic, palmitoleic and oleic acids, and the contents of essential fatty acids are unchanged." @default.
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- W2034756284 date "1965-07-01" @default.
- W2034756284 modified "2023-09-23" @default.
- W2034756284 title "A raised level of free fatty acids in serum of rats deficient in essential fatty acids as a contributing cause of their fatty livers" @default.
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- W2034756284 doi "https://doi.org/10.1016/0005-2760(65)90113-x" @default.
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