FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034756609> ?p ?o ?g. }

• W2034756609 abstract "Abstract Background Cochlear hair cells are high-frequency sensory receptors. At the onset of hearing, hair cells acquire fast, calcium-activated potassium (BK) currents, turning immature spiking cells into functional receptors. In non-mammalian vertebrates, the number and kinetics of BK channels are varied systematically along the frequency-axis of the cochlea giving rise to an intrinsic electrical tuning mechanism. The processes that control the appearance and heterogeneity of hair cell BK currents remain unclear. Results Quantitative PCR results showed a non-monotonic increase in BK α subunit expression throughout embryonic development of the chick auditory organ (i.e. basilar papilla). Expression peaked near embryonic day (E) 19 with six times the transcript level of E11 sensory epithelia. The steady increase in gene expression from E11 to E19 could not explain the sudden acquisition of currents at E18-19, implicating post-transcriptional mechanisms. Protein expression also preceded function but progressed in a sequence from diffuse cytoplasmic staining at early ages to punctate membrane-bound clusters at E18. Electrophysiology data confirmed a continued refinement of BK trafficking from E18 to E20, indicating a translocation of BK clusters from supranuclear to subnuclear domains over this critical developmental age. Conclusions Gene products encoding BK α subunits are detected up to 8 days before the acquisition of anti-BK clusters and functional BK currents. Therefore, post-transcriptional mechanisms seem to play a key role in the delayed emergence of calcium-sensitive currents. We suggest that regulation of translation and trafficking of functional α subunits, near voltage-gated calcium channels, leads to functional BK currents at the onset of hearing." @default.
• W2034756609 created "2016-06-24" @default.
• W2034756609 creator A5017542142 @default.
• W2034756609 creator A5061416969 @default.
• W2034756609 creator A5063337257 @default.
• W2034756609 creator A5064842058 @default.
• W2034756609 creator A5067720825 @default.
• W2034756609 creator A5073358304 @default.
• W2034756609 date "2009-12-01" @default.
• W2034756609 modified "2023-10-17" @default.
• W2034756609 title "Developmental expression of BK channels in chick cochlear hair cells" @default.
• W2034756609 cites W1481691462 @default.
• W2034756609 cites W1490213597 @default.
• W2034756609 cites W1606945552 @default.
• W2034756609 cites W1884550795 @default.
• W2034756609 cites W1900274922 @default.
• W2034756609 cites W1972890156 @default.
• W2034756609 cites W1976381353 @default.
• W2034756609 cites W1976505330 @default.
• W2034756609 cites W1977745877 @default.
• W2034756609 cites W1991983993 @default.
• W2034756609 cites W1992995631 @default.
• W2034756609 cites W1994471332 @default.
• W2034756609 cites W1995813554 @default.
• W2034756609 cites W1996443549 @default.
• W2034756609 cites W2005558197 @default.
• W2034756609 cites W2006353836 @default.
• W2034756609 cites W2009452903 @default.
• W2034756609 cites W2009667219 @default.
• W2034756609 cites W2011254936 @default.
• W2034756609 cites W2011415025 @default.
• W2034756609 cites W2014264924 @default.
• W2034756609 cites W2015453018 @default.
• W2034756609 cites W2018408627 @default.
• W2034756609 cites W2023164168 @default.
• W2034756609 cites W2024358207 @default.
• W2034756609 cites W2025017045 @default.
• W2034756609 cites W2025255849 @default.
• W2034756609 cites W2028798056 @default.
• W2034756609 cites W2030755571 @default.
• W2034756609 cites W2036476211 @default.
• W2034756609 cites W2036515774 @default.
• W2034756609 cites W2038561453 @default.
• W2034756609 cites W2044382647 @default.
• W2034756609 cites W2051067605 @default.
• W2034756609 cites W2053068031 @default.
• W2034756609 cites W2056581027 @default.
• W2034756609 cites W2058615127 @default.
• W2034756609 cites W2061197019 @default.
• W2034756609 cites W2066363179 @default.
• W2034756609 cites W2072757479 @default.
• W2034756609 cites W2074378742 @default.
• W2034756609 cites W2077980343 @default.
• W2034756609 cites W2079297169 @default.
• W2034756609 cites W2079391496 @default.
• W2034756609 cites W2083124003 @default.
• W2034756609 cites W2085534162 @default.
• W2034756609 cites W2091448118 @default.
• W2034756609 cites W2093680082 @default.
• W2034756609 cites W2095766063 @default.
• W2034756609 cites W2096196059 @default.
• W2034756609 cites W2098503950 @default.
• W2034756609 cites W2100619983 @default.
• W2034756609 cites W2107277218 @default.
• W2034756609 cites W2107363136 @default.
• W2034756609 cites W2117171932 @default.
• W2034756609 cites W2117788987 @default.
• W2034756609 cites W2118365328 @default.
• W2034756609 cites W2122563317 @default.
• W2034756609 cites W2125668807 @default.
• W2034756609 cites W2127972211 @default.
• W2034756609 cites W2137850358 @default.
• W2034756609 cites W2140150081 @default.
• W2034756609 cites W2140236160 @default.
• W2034756609 cites W2141394516 @default.
• W2034756609 cites W2142184282 @default.
• W2034756609 cites W2144527553 @default.
• W2034756609 cites W2146950413 @default.
• W2034756609 cites W2148149399 @default.
• W2034756609 cites W2155479958 @default.
• W2034756609 cites W2157619218 @default.
• W2034756609 cites W2170949754 @default.
• W2034756609 cites W2230388424 @default.
• W2034756609 cites W2318738095 @default.
• W2034756609 cites W4241872693 @default.
• W2034756609 cites W4246520054 @default.
• W2034756609 doi "https://doi.org/10.1186/1471-213x-9-67" @default.
• W2034756609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2803478" @default.
• W2034756609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20003519" @default.
• W2034756609 hasPublicationYear "2009" @default.
• W2034756609 type Work @default.
• W2034756609 sameAs 2034756609 @default.
• W2034756609 citedByCount "9" @default.
• W2034756609 countsByYear W20347566092013 @default.
• W2034756609 countsByYear W20347566092014 @default.
• W2034756609 countsByYear W20347566092016 @default.
• W2034756609 countsByYear W20347566092017 @default.
• W2034756609 countsByYear W20347566092022 @default.
• W2034756609 crossrefType "journal-article" @default.
• W2034756609 hasAuthorship W2034756609A5017542142 @default.

• next