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- W2034756824 startingPage "e34803" @default.
- W2034756824 abstract "Glucose is a fundamental energy source for both prokaryotes and eukaryotes. The balance between glucose utilization and storage is integral for proper energy homeostasis, and defects are associated with several diseases, e.g. type II diabetes. In vertebrates, the transcription factor ChREBP is a major component in glucose metabolism, while its ortholog MondoA is involved in glucose uptake. Both MondoA and ChREBP contain five Mondo conserved regions (MCRI-V) that affect their cellular localization and transactivation ability. While phosphorylation has been shown to affect ChREBP function, the mechanisms controlling glucose response of both ChREBP and MondoA remain elusive. By incorporating sequence analysis techniques, structure predictions, and functional annotations, we synthesized data surrounding Mondo family proteins into a cohesive, accurate, and general model involving the MCRs and two additional domains that determine ChREBP and MondoA glucose response. Paramount, we identified a conserved motif within the transactivation region of Mondo family proteins and propose that this motif interacts with the phosphorylated form of glucose. In addition, we discovered a putative nuclear receptor box in non-vertebrate Mondo and vertebrate ChREBP sequences that reveals a potentially novel interaction with nuclear receptors. These interactions are likely involved in altering ChREBP and MondoA conformation to form an active complex and induce transcription of genes involved in glucose metabolism and lipogenesis." @default.
- W2034756824 created "2016-06-24" @default.
- W2034756824 creator A5005988809 @default.
- W2034756824 creator A5063689308 @default.
- W2034756824 date "2012-04-10" @default.
- W2034756824 modified "2023-10-11" @default.
- W2034756824 title "A Novel N-Terminal Domain May Dictate the Glucose Response of Mondo Proteins" @default.
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- W2034756824 doi "https://doi.org/10.1371/journal.pone.0034803" @default.
- W2034756824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3323566" @default.
- W2034756824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22506051" @default.
- W2034756824 hasPublicationYear "2012" @default.
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