FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034756951> ?p ?o ?g. }

• W2034756951 endingPage "1189" @default.
• W2034756951 startingPage "1178" @default.
• W2034756951 abstract "Spinal proinflammatory cytokines are powerful pain-enhancing signals that contribute to pain following peripheral nerve injury (neuropathic pain). Recently, one proinflammatory cytokine, interleukin-1, was also implicated in the loss of analgesia upon repeated morphine exposure (tolerance). In contrast to prior literature, we demonstrate that the action of several spinal proinflammatory cytokines oppose systemic and intrathecal opioid analgesia, causing reduced pain suppression. In vitro morphine exposure of lumbar dorsal spinal cord caused significant increases in proinflammatory cytokine and chemokine release. Opposition of analgesia by proinflammatory cytokines is rapid, occurring < or =5 min after intrathecal (perispinal) opioid administration. We document that opposition of analgesia by proinflammatory cytokines cannot be accounted for by an alteration in spinal morphine concentrations. The acute anti-analgesic effects of proinflammatory cytokines occur in a p38 mitogen-activated protein kinase and nitric oxide dependent fashion. Chronic intrathecal morphine or methadone significantly increased spinal glial activation (toll-like receptor 4 mRNA and protein) and the expression of multiple chemokines and cytokines, combined with development of analgesic tolerance and pain enhancement (hyperalgesia, allodynia). Statistical analysis demonstrated that a cluster of cytokines and chemokines was linked with pain-related behavioral changes. Moreover, blockade of spinal proinflammatory cytokines during a stringent morphine regimen previously associated with altered neuronal function also attenuated enhanced pain, supportive that proinflammatory cytokines are importantly involved in tolerance induced by such regimens. These data implicate multiple opioid-induced spinal proinflammatory cytokines in opposing both acute and chronic opioid analgesia, and provide a novel mechanism for the opposition of acute opioid analgesia." @default.
• W2034756951 created "2016-06-24" @default.
• W2034756951 creator A5010030770 @default.
• W2034756951 creator A5011957342 @default.
• W2034756951 creator A5013563265 @default.
• W2034756951 creator A5017789225 @default.
• W2034756951 creator A5025282582 @default.
• W2034756951 creator A5036750960 @default.
• W2034756951 creator A5037100405 @default.
• W2034756951 creator A5038338674 @default.
• W2034756951 creator A5042845262 @default.
• W2034756951 creator A5061812047 @default.
• W2034756951 creator A5064897861 @default.
• W2034756951 creator A5072193055 @default.
• W2034756951 creator A5082830689 @default.
• W2034756951 creator A5089827696 @default.
• W2034756951 creator A5090171524 @default.
• W2034756951 date "2008-11-01" @default.
• W2034756951 modified "2023-10-14" @default.
• W2034756951 title "Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia" @default.
• W2034756951 cites W1969013604 @default.
• W2034756951 cites W1969262598 @default.
• W2034756951 cites W1972467982 @default.
• W2034756951 cites W1974093633 @default.
• W2034756951 cites W1980942228 @default.
• W2034756951 cites W1981014302 @default.
• W2034756951 cites W1993110961 @default.
• W2034756951 cites W1995031937 @default.
• W2034756951 cites W1997093375 @default.
• W2034756951 cites W2002737496 @default.
• W2034756951 cites W2006680088 @default.
• W2034756951 cites W2008301670 @default.
• W2034756951 cites W2009564706 @default.
• W2034756951 cites W2012219502 @default.
• W2034756951 cites W2014007136 @default.
• W2034756951 cites W2016448869 @default.
• W2034756951 cites W2031036912 @default.
• W2034756951 cites W2036033786 @default.
• W2034756951 cites W2036436547 @default.
• W2034756951 cites W2052193782 @default.
• W2034756951 cites W2056688527 @default.
• W2034756951 cites W2062728888 @default.
• W2034756951 cites W2064548402 @default.
• W2034756951 cites W2065514611 @default.
• W2034756951 cites W2068399246 @default.
• W2034756951 cites W2073224410 @default.
• W2034756951 cites W2073868390 @default.
• W2034756951 cites W2089211646 @default.
• W2034756951 cites W2094909468 @default.
• W2034756951 cites W2096906979 @default.
• W2034756951 cites W2103801183 @default.
• W2034756951 cites W2106100751 @default.
• W2034756951 cites W2116862546 @default.
• W2034756951 cites W2116903459 @default.
• W2034756951 cites W2122571786 @default.
• W2034756951 cites W2124355299 @default.
• W2034756951 cites W2124673849 @default.
• W2034756951 cites W2131810796 @default.
• W2034756951 cites W2133707124 @default.
• W2034756951 cites W2140193821 @default.
• W2034756951 cites W2140821992 @default.
• W2034756951 cites W2155784716 @default.
• W2034756951 cites W2156364336 @default.
• W2034756951 cites W2166567046 @default.
• W2034756951 cites W2170019750 @default.
• W2034756951 cites W2172201406 @default.
• W2034756951 cites W4246072030 @default.
• W2034756951 doi "https://doi.org/10.1016/j.bbi.2008.05.004" @default.
• W2034756951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2783238" @default.
• W2034756951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18599265" @default.
• W2034756951 hasPublicationYear "2008" @default.
• W2034756951 type Work @default.
• W2034756951 sameAs 2034756951 @default.
• W2034756951 citedByCount "267" @default.
• W2034756951 countsByYear W20347569512012 @default.
• W2034756951 countsByYear W20347569512013 @default.
• W2034756951 countsByYear W20347569512014 @default.
• W2034756951 countsByYear W20347569512015 @default.
• W2034756951 countsByYear W20347569512016 @default.
• W2034756951 countsByYear W20347569512017 @default.
• W2034756951 countsByYear W20347569512018 @default.
• W2034756951 countsByYear W20347569512019 @default.
• W2034756951 countsByYear W20347569512020 @default.
• W2034756951 countsByYear W20347569512021 @default.
• W2034756951 countsByYear W20347569512022 @default.
• W2034756951 countsByYear W20347569512023 @default.
• W2034756951 crossrefType "journal-article" @default.
• W2034756951 hasAuthorship W2034756951A5010030770 @default.
• W2034756951 hasAuthorship W2034756951A5011957342 @default.
• W2034756951 hasAuthorship W2034756951A5013563265 @default.
• W2034756951 hasAuthorship W2034756951A5017789225 @default.
• W2034756951 hasAuthorship W2034756951A5025282582 @default.
• W2034756951 hasAuthorship W2034756951A5036750960 @default.
• W2034756951 hasAuthorship W2034756951A5037100405 @default.
• W2034756951 hasAuthorship W2034756951A5038338674 @default.
• W2034756951 hasAuthorship W2034756951A5042845262 @default.
• W2034756951 hasAuthorship W2034756951A5061812047 @default.
• W2034756951 hasAuthorship W2034756951A5064897861 @default.

• next