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• W2034757955 abstract "Previous studies have shown that prostaglandin E2 (PGE2) and vitamin E succinate can act in an additive manner to inhibit the proliferation of human oral squamous carcinoma cells (SCC-25). The initial studies on the additive anticancer activity of PGE2 and vitamin E succinate have been extended to include antineoplastic PGs, delta 12-PGJ2 and PGJ2. Treatment of oral squamous carcinoma cells (SCC-15) with delta 12-PGJ2, PGJ2, and vitamin E succinate, individually, caused significant concentration-dependent inhibition of cell proliferation to various degrees. PGJ2 was most potent and caused an inhibition that corresponded to 85.55% at 10(-5) M. Addition of 1 microM of vitamin E succinate to delta 12-PGJ2 or PGJ2 resulted in a significant increase in the inhibitory potency of the lower concentrations of the two PGs. These results suggest a novel role for a mixture of PGs and vitamin E as potent antitumor proliferative agents." @default.
• W2034757955 created "2016-06-24" @default.
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• W2034757955 date "1995-01-01" @default.
• W2034757955 modified "2023-09-27" @default.
• W2034757955 title "Vitamin e succinate potentiates the inhibitory effect of prostaglandins on oral squamous carcinoma cell proliferation" @default.
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• W2034757955 doi "https://doi.org/10.1016/0952-3278(95)90099-3" @default.
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