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• W2034758332 abstract "The diffusion of calcium inside neurons is determined in part by the intracellular calcium binding species that rapidly bind to free calcium ions upon entry. It has long been known that some portion of a neuron’s intracellular calcium binding capacity must be fixed or poorly mobile, as calcium diffusion is strongly slowed in the intracellular environment relative to diffusion in cytosolic extract. The working assumption was that these immobile calcium binding sites are provided by structural proteins bound to the cytoskeleton or intracellular membranes and may thereby be relatively similar in composition and capacity across different cell types. However recent evidence suggests that the immobile buffering capacity can vary greatly between cell types and that some mobile calcium binding proteins may alter their mobility upon binding calcium, thus blurring the line between mobile and immobile. The ways in which immobile buffering capacity might be relevant to different calcium domains within neurons has been explored primarily through modeling. In certain regimes, the presence of immobile buffers and the interaction between mobile and immobile buffers have been shown to result in complex spatiotemporal patterns of free calcium. In total, these experimental and modeling findings call for a more nuanced consideration of the local intracellular calcium microenvironment. In this review we focus on the different amounts, affinities, and mobilities of immobile calcium binding species; propose a new conceptual category of physically diffusible but functionally immobile buffers; and discuss how these buffers might interact with mobile calcium binding partners to generate characteristic calcium domains." @default.
• W2034758332 created "2016-06-24" @default.
• W2034758332 creator A5033497484 @default.
• W2034758332 creator A5043911494 @default.
• W2034758332 date "2015-02-20" @default.
• W2034758332 modified "2023-10-11" @default.
• W2034758332 title "Buffer mobility and the regulation of neuronal calcium domains" @default.
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• W2034758332 doi "https://doi.org/10.3389/fncel.2015.00048" @default.
• W2034758332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4335178" @default.
• W2034758332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25750615" @default.
• W2034758332 hasPublicationYear "2015" @default.
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