FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034762247> ?p ?o ?g. }

• W2034762247 endingPage "264" @default.
• W2034762247 startingPage "259" @default.
• W2034762247 abstract "Background The purposes of this study were: 1) to examine the influence of endothelin (ET-1) release on the ability of angiotensin (Ang) II to modulate permeability, 2) to determine if the action of Ang II on microvascular permeability is dependent on nitric oxide (NO) release, and 3) to explore the effect of Ang II in microvessels activated with platelet activating factor (PAF). Methods Hydraulic permeability (Lp) was measured using the modified Landis in vivo micro occlusion technique during perfusion with: 1) the ET-1 receptor antagonist PD145065 (50 μm), then PD145065 + Ang II, 2) Ang II (20 nm), a NO synthase inhibitor l-NAME (100 μm), then l-NAME + Ang II, and 3) after endothelial activation with 10 nm of PAF, then PAF + Ang II. Results 1) The ET-1 antagonist increased Lp 2.5-fold, Ang II alone increased Lp five-fold, while Ang II perfusion during ET-1 antagonism increased Lp over 6-fold (P < 0.04); 2) l-NAME increased Lp over 3-fold. Ang II perfusion during NO synthase inhibition had no effect compared to NO synthase inhibition alone (P = 0.9) while Ang II alone increased Lp 5-fold (P ≤ 0.01); 3) PAF + Ang II (Lp = 2.74 ± 0.12) was decreased versus PAF alone (Lp = 4.66 ± 0.25) (P < 0.02). Conclusions Ang II does not increase hydraulic permeability via ET-1 release. Ang II may act via NO release to increase hydraulic permeability in the basal state. Finally, Ang II attenuates the increase in hydraulic permeability because of endothelial activation with platelet activating factor. The purposes of this study were: 1) to examine the influence of endothelin (ET-1) release on the ability of angiotensin (Ang) II to modulate permeability, 2) to determine if the action of Ang II on microvascular permeability is dependent on nitric oxide (NO) release, and 3) to explore the effect of Ang II in microvessels activated with platelet activating factor (PAF). Hydraulic permeability (Lp) was measured using the modified Landis in vivo micro occlusion technique during perfusion with: 1) the ET-1 receptor antagonist PD145065 (50 μm), then PD145065 + Ang II, 2) Ang II (20 nm), a NO synthase inhibitor l-NAME (100 μm), then l-NAME + Ang II, and 3) after endothelial activation with 10 nm of PAF, then PAF + Ang II. 1) The ET-1 antagonist increased Lp 2.5-fold, Ang II alone increased Lp five-fold, while Ang II perfusion during ET-1 antagonism increased Lp over 6-fold (P < 0.04); 2) l-NAME increased Lp over 3-fold. Ang II perfusion during NO synthase inhibition had no effect compared to NO synthase inhibition alone (P = 0.9) while Ang II alone increased Lp 5-fold (P ≤ 0.01); 3) PAF + Ang II (Lp = 2.74 ± 0.12) was decreased versus PAF alone (Lp = 4.66 ± 0.25) (P < 0.02). Ang II does not increase hydraulic permeability via ET-1 release. Ang II may act via NO release to increase hydraulic permeability in the basal state. Finally, Ang II attenuates the increase in hydraulic permeability because of endothelial activation with platelet activating factor." @default.
• W2034762247 created "2016-06-24" @default.
• W2034762247 creator A5034238737 @default.
• W2034762247 creator A5060451007 @default.
• W2034762247 creator A5086731891 @default.
• W2034762247 date "2006-08-01" @default.
• W2034762247 modified "2023-09-27" @default.
• W2034762247 title "Angiotensin II Effect on Hydraulic Permeability: Interaction with Endothelin-1, Nitric Oxide, and Platelet Activating Factor" @default.
• W2034762247 cites W1965948991 @default.
• W2034762247 cites W1976512520 @default.
• W2034762247 cites W1979840934 @default.
• W2034762247 cites W1979971980 @default.
• W2034762247 cites W1979973530 @default.
• W2034762247 cites W1986123217 @default.
• W2034762247 cites W2008356024 @default.
• W2034762247 cites W2014394353 @default.
• W2034762247 cites W2021338951 @default.
• W2034762247 cites W2027280654 @default.
• W2034762247 cites W2035867567 @default.
• W2034762247 cites W2037954367 @default.
• W2034762247 cites W2066157167 @default.
• W2034762247 cites W2070597284 @default.
• W2034762247 cites W2080422687 @default.
• W2034762247 cites W2082603208 @default.
• W2034762247 cites W2082920336 @default.
• W2034762247 cites W2083438918 @default.
• W2034762247 cites W2089270280 @default.
• W2034762247 cites W2105300577 @default.
• W2034762247 cites W2119380751 @default.
• W2034762247 cites W2143535523 @default.
• W2034762247 cites W2162804111 @default.
• W2034762247 cites W2171686436 @default.
• W2034762247 cites W2409761204 @default.
• W2034762247 cites W2411013230 @default.
• W2034762247 cites W2412344000 @default.
• W2034762247 cites W2436954253 @default.
• W2034762247 doi "https://doi.org/10.1016/j.jss.2006.01.017" @default.
• W2034762247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16515797" @default.
• W2034762247 hasPublicationYear "2006" @default.
• W2034762247 type Work @default.
• W2034762247 sameAs 2034762247 @default.
• W2034762247 citedByCount "5" @default.
• W2034762247 countsByYear W20347622472015 @default.
• W2034762247 crossrefType "journal-article" @default.
• W2034762247 hasAuthorship W2034762247A5034238737 @default.
• W2034762247 hasAuthorship W2034762247A5060451007 @default.
• W2034762247 hasAuthorship W2034762247A5086731891 @default.
• W2034762247 hasConcept C120882062 @default.
• W2034762247 hasConcept C126322002 @default.
• W2034762247 hasConcept C134018914 @default.
• W2034762247 hasConcept C149601957 @default.
• W2034762247 hasConcept C170493617 @default.
• W2034762247 hasConcept C185592680 @default.
• W2034762247 hasConcept C2776885963 @default.
• W2034762247 hasConcept C2777622882 @default.
• W2034762247 hasConcept C2778122271 @default.
• W2034762247 hasConcept C2779020240 @default.
• W2034762247 hasConcept C2908929049 @default.
• W2034762247 hasConcept C41625074 @default.
• W2034762247 hasConcept C519581460 @default.
• W2034762247 hasConcept C55493867 @default.
• W2034762247 hasConcept C71924100 @default.
• W2034762247 hasConcept C98274493 @default.
• W2034762247 hasConceptScore W2034762247C120882062 @default.
• W2034762247 hasConceptScore W2034762247C126322002 @default.
• W2034762247 hasConceptScore W2034762247C134018914 @default.
• W2034762247 hasConceptScore W2034762247C149601957 @default.
• W2034762247 hasConceptScore W2034762247C170493617 @default.
• W2034762247 hasConceptScore W2034762247C185592680 @default.
• W2034762247 hasConceptScore W2034762247C2776885963 @default.
• W2034762247 hasConceptScore W2034762247C2777622882 @default.
• W2034762247 hasConceptScore W2034762247C2778122271 @default.
• W2034762247 hasConceptScore W2034762247C2779020240 @default.
• W2034762247 hasConceptScore W2034762247C2908929049 @default.
• W2034762247 hasConceptScore W2034762247C41625074 @default.
• W2034762247 hasConceptScore W2034762247C519581460 @default.
• W2034762247 hasConceptScore W2034762247C55493867 @default.
• W2034762247 hasConceptScore W2034762247C71924100 @default.
• W2034762247 hasConceptScore W2034762247C98274493 @default.
• W2034762247 hasIssue "2" @default.
• W2034762247 hasLocation W20347622471 @default.
• W2034762247 hasLocation W20347622472 @default.
• W2034762247 hasOpenAccess W2034762247 @default.
• W2034762247 hasPrimaryLocation W20347622471 @default.
• W2034762247 hasRelatedWork W1971613811 @default.
• W2034762247 hasRelatedWork W1992689150 @default.
• W2034762247 hasRelatedWork W2062269899 @default.
• W2034762247 hasRelatedWork W2074912007 @default.
• W2034762247 hasRelatedWork W2083576828 @default.
• W2034762247 hasRelatedWork W2110143838 @default.
• W2034762247 hasRelatedWork W2162471541 @default.
• W2034762247 hasRelatedWork W2393521223 @default.
• W2034762247 hasRelatedWork W2413658046 @default.
• W2034762247 hasRelatedWork W2563938602 @default.
• W2034762247 hasVolume "134" @default.
• W2034762247 isParatext "false" @default.
• W2034762247 isRetracted "false" @default.
• W2034762247 magId "2034762247" @default.

• next