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• W2034763014 abstract "We investigated the mechanisms of pyruvate transport in the erythrocytes of an ancient marine agnathan, the Pacific hagfish (Eptatretus stouti), and a sedentary euryhaline teleost, the starry flounder (Platichthys stellatus). Uptake of [ 14 C]pyruvate (50 µM, 10°C) by flounder erythrocytes was slow (t 1/2 (half-life) ~ 30 min), nonconcentrative, and mediated by the band 3 Cl - /HCO - 3 exchanger in combination with a process similar to the H + /monocarboxylate symporter present in freshwater teleosts and mammalian erythrocytes. In contrast, pyruvate uptake by hagfish erythrocytes (50 µM, 10°C) was rapid (t 1/2 ~ 1.5 min) and, in 10 min, reached an intracellular concentration more than 20-fold higher than that present in the extracellular medium. Pyruvate accounted for almost 90% of the accumulated intracellular radioactivity, the remaining label being incorporated into tricarboxylic acid cycle intermediates and glutamate. Influx of pyruvate was saturable (apparent K m = 12 mM) and inhibited by p-chloromercuriphenylsulphonate (PCMBS) (K i = 71 µM) and 4,4'-diisothiocyanatostilbene-2,2'-disulphonate (DIDS) (K i = 0.49 mM). Transport was inhibited poorly by α-cyano-4-hydroxycinnamate (CIN) (K i > 4 mM) and was not coupled to the movement of protons. Instead, the influx of pyruvate was Na + dependent. A sigmoidal relationship between pyruvate transport and extracellular Na + concentration was observed, suggesting a Na + :pyruvate coupling ratio greater than 1:1. In contrast with previously described Na + -dependent monocarboxylate transport activities in mammalian renal and intestinal epithelia, the hagfish erythrocyte system did not transport lactate." @default.
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• W2034763014 date "2000-11-01" @default.
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• W2034763014 title "Na+-dependent transport of pyruvate in erythrocytes of the Pacific hagfish (Eptatretus stouti)" @default.
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• W2034763014 doi "https://doi.org/10.1139/z00-145" @default.
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