FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034768511> ?p ?o ?g. }

• W2034768511 endingPage "1776" @default.
• W2034768511 startingPage "1765" @default.
• W2034768511 abstract "The ability to pattern multiple bioactive cues on a surface is valuable for understanding how neurons interact with their complex extracellular environment. In this report, we introduce a set of methods for creating such surfaces, with the goals of understanding how developing neurons integrate multiple biologically relevant signals and as a tool for studying interactions between multiple neurons. Multiple microcontact printing steps are combined on a single surface to produce an array of polylysine nodes, interconnected by lines of proteins based on the extracellular domains of L1 or N-cadherin. Surprisingly, the N-cadherin protein could also be directly printed onto surfaces while retaining its biological activity. Rat hippocampal neurons selectively attached to the polylysine nodes, differentially extending axonal and dendritic processes along the patterns of L1 and N-cadherin, thus demonstrating control over neuron attachment and outgrowth. Combining these three biomolecules on a single surface revealed a highly complex pattern of protein recognition. Dendrites extended exclusively on N-cadherin patterns, while axons exhibited a very high degree of selectivity on L1 patterns, preferentially at distances greater than 55 mum from the cell body. At shorter distances, axonal processes recognized both L1 and N-cadherin, revealing a new aspect of neuron polarity and axon specification. This onset of L1 selectivity correlated with the establishment of intracellular L1 polarity, suggesting a functional outcome of the process of neuron polarization that has implications in development of neural tissues and creation of in vitro neuron networks." @default.
• W2034768511 created "2016-06-24" @default.
• W2034768511 creator A5010642020 @default.
• W2034768511 creator A5011076443 @default.
• W2034768511 creator A5049336001 @default.
• W2034768511 date "2007-01-01" @default.
• W2034768511 modified "2023-10-16" @default.
• W2034768511 title "Local presentation of L1 and N-cadherin in multicomponent, microscale patterns differentially direct neuron functionin vitro" @default.
• W2034768511 cites W110398411 @default.
• W2034768511 cites W1564192489 @default.
• W2034768511 cites W1603204648 @default.
• W2034768511 cites W1912510903 @default.
• W2034768511 cites W1934147889 @default.
• W2034768511 cites W1963611337 @default.
• W2034768511 cites W1973746811 @default.
• W2034768511 cites W1977959097 @default.
• W2034768511 cites W1981817841 @default.
• W2034768511 cites W1982460275 @default.
• W2034768511 cites W1983352401 @default.
• W2034768511 cites W1983491648 @default.
• W2034768511 cites W1994391606 @default.
• W2034768511 cites W1997290503 @default.
• W2034768511 cites W2002545202 @default.
• W2034768511 cites W2012354516 @default.
• W2034768511 cites W2021701663 @default.
• W2034768511 cites W2024280070 @default.
• W2034768511 cites W2048191546 @default.
• W2034768511 cites W2053552455 @default.
• W2034768511 cites W2055804746 @default.
• W2034768511 cites W2056435370 @default.
• W2034768511 cites W2060919797 @default.
• W2034768511 cites W2067862351 @default.
• W2034768511 cites W2110014101 @default.
• W2034768511 cites W2124813164 @default.
• W2034768511 cites W2131027980 @default.
• W2034768511 cites W2160084586 @default.
• W2034768511 cites W2163822035 @default.
• W2034768511 cites W2376305620 @default.
• W2034768511 cites W4238839969 @default.
• W2034768511 doi "https://doi.org/10.1002/dneu.20553" @default.
• W2034768511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17659593" @default.
• W2034768511 hasPublicationYear "2007" @default.
• W2034768511 type Work @default.
• W2034768511 sameAs 2034768511 @default.
• W2034768511 citedByCount "58" @default.
• W2034768511 countsByYear W20347685112012 @default.
• W2034768511 countsByYear W20347685112013 @default.
• W2034768511 countsByYear W20347685112014 @default.
• W2034768511 countsByYear W20347685112015 @default.
• W2034768511 countsByYear W20347685112016 @default.
• W2034768511 countsByYear W20347685112017 @default.
• W2034768511 countsByYear W20347685112018 @default.
• W2034768511 countsByYear W20347685112019 @default.
• W2034768511 countsByYear W20347685112020 @default.
• W2034768511 countsByYear W20347685112021 @default.
• W2034768511 countsByYear W20347685112022 @default.
• W2034768511 countsByYear W20347685112023 @default.
• W2034768511 crossrefType "journal-article" @default.
• W2034768511 hasAuthorship W2034768511A5010642020 @default.
• W2034768511 hasAuthorship W2034768511A5011076443 @default.
• W2034768511 hasAuthorship W2034768511A5049336001 @default.
• W2034768511 hasConcept C1491633281 @default.
• W2034768511 hasConcept C149402561 @default.
• W2034768511 hasConcept C169760540 @default.
• W2034768511 hasConcept C171250308 @default.
• W2034768511 hasConcept C192562407 @default.
• W2034768511 hasConcept C2778794669 @default.
• W2034768511 hasConcept C2779530196 @default.
• W2034768511 hasConcept C2780075363 @default.
• W2034768511 hasConcept C28406088 @default.
• W2034768511 hasConcept C49353375 @default.
• W2034768511 hasConcept C55493867 @default.
• W2034768511 hasConcept C58943365 @default.
• W2034768511 hasConcept C69125201 @default.
• W2034768511 hasConcept C86803240 @default.
• W2034768511 hasConcept C95444343 @default.
• W2034768511 hasConceptScore W2034768511C1491633281 @default.
• W2034768511 hasConceptScore W2034768511C149402561 @default.
• W2034768511 hasConceptScore W2034768511C169760540 @default.
• W2034768511 hasConceptScore W2034768511C171250308 @default.
• W2034768511 hasConceptScore W2034768511C192562407 @default.
• W2034768511 hasConceptScore W2034768511C2778794669 @default.
• W2034768511 hasConceptScore W2034768511C2779530196 @default.
• W2034768511 hasConceptScore W2034768511C2780075363 @default.
• W2034768511 hasConceptScore W2034768511C28406088 @default.
• W2034768511 hasConceptScore W2034768511C49353375 @default.
• W2034768511 hasConceptScore W2034768511C55493867 @default.
• W2034768511 hasConceptScore W2034768511C58943365 @default.
• W2034768511 hasConceptScore W2034768511C69125201 @default.
• W2034768511 hasConceptScore W2034768511C86803240 @default.
• W2034768511 hasConceptScore W2034768511C95444343 @default.
• W2034768511 hasIssue "13" @default.
• W2034768511 hasLocation W20347685111 @default.
• W2034768511 hasLocation W20347685112 @default.
• W2034768511 hasOpenAccess W2034768511 @default.
• W2034768511 hasPrimaryLocation W20347685111 @default.
• W2034768511 hasRelatedWork W1961849937 @default.
• W2034768511 hasRelatedWork W1986155324 @default.

• next