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- W2034770040 abstract "The justification for strategies to control major human helminth infections has been clearly set out by Gabrielli et al.1 There is an obvious need to try to reduce infection and morbidity with the ultimate aim of eradication of infections. However, experience with helminths of domesticated animals indicates that the development of resistance is an almost inevitable consequence of mass use of anthelminthics. Therefore, it is essential in any control programme that possible development of resistance is monitored and that the efficacy of an anthelminthic in one region is confirmed prior to its mass use. The ability to detect benzimidazole (albendazole) resistance has been made much simpler by the recent publication of Vercruysse et al.2 who have suggested that the expected therapeutic efficacy, as assessed by faecal egg count reduction, should be >95% for Ascaris lumbricoides and >90% for hookworms. There is evidence that resistance may be developing to benzimidazoles in hookworms3,4 which is not surprising if albendazole removes only >90% of hookworms. With susceptible nematodes in sheep benzimidazole efficacy should be at least 98% (G. Cringoli et al., unpublished data) and yet resistance developed relatively rapidly. The low efficacy of albendazole against Trichuris trichuria2 can possibly be explained by the polymorphism of β-tubulin5 which means that repeated use of albendazole against this species can be expected to result in rapid reduction of activity." @default.
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- W2034770040 date "2012-05-01" @default.
- W2034770040 modified "2023-09-27" @default.
- W2034770040 title "Comment on: Preventive chemotherapy in human helminthiasis: theoretical and operational aspects" @default.
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- W2034770040 doi "https://doi.org/10.1016/j.trstmh.2012.02.005" @default.
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