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- W2034771321 abstract "Human cells respond to DNA damage with an acute and transient burst in production of poly(ADP-ribose), a posttranslational modification that expedites damage repair and plays a pivotal role in cell fate decisions. Poly(ADP-ribose) polymerases (PARPs) and glycohydrolase (PARG) are the key set of enzymes that orchestrate the rise and fall in cellular levels of poly(ADP-ribose). In this perspective, we focus on recent structural and mechanistic insights into the enzymes involved in poly(ADP-ribose) production and turnover, and we highlight important questions that remain to be answered." @default.
- W2034771321 created "2016-06-24" @default.
- W2034771321 creator A5017027620 @default.
- W2034771321 creator A5056306966 @default.
- W2034771321 date "2015-08-01" @default.
- W2034771321 modified "2023-10-18" @default.
- W2034771321 title "The rise and fall of poly(ADP-ribose): An enzymatic perspective" @default.
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- W2034771321 doi "https://doi.org/10.1016/j.dnarep.2015.04.008" @default.
- W2034771321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4522361" @default.
- W2034771321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25963443" @default.
- W2034771321 hasPublicationYear "2015" @default.
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