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- W2034771653 abstract "Zearalenone (ZEA) is a mycotoxin of worldwide occurrence, and it has been shown to produce numerous adverse effects in both laboratory and domestic animals. However, regardless of recent achievements, the molecular mechanisms underlying ZEA toxicity remain elusive, and little is known about transcriptome changes of fish cells in response to ZEA occurrence. In the present study, differential display PCR was used to generate a unique cDNA fingerprint of differentially expressed transcripts in the liver and ovary of juvenile rainbow trout after either 24, 72, or 168 h of intraperitoneal exposure to ZEA (10 mg/kg of body mass). From a total of 59 isolated cDNA bands (ESTs), 5 could be confirmed with Real-Time qPCR and their nucleotide sequences were identified as mRNAs of: acty (β-centractin), the cytoskeleton structural element; bccip, responsible for DNA repair and cell cycle control; enoa (α-enolase), encoding enzyme of the glycolysis process; proc (protein C), that takes part in the blood coagulation process; and frih, encoding the heavy chain of ferritin, the protein complex important for iron storage. Further qPCR analysis of the confirmed ESTs expression profiles revealed significant mRNA level alterations in both tissues of exposed fish during the 168 h study. The results revealed a complex network of genes associated with different biological processes that may be engaged in the cellular response to ZEA exposure, i.e. blood coagulation or iron-storage processes." @default.
- W2034771653 created "2016-06-24" @default.
- W2034771653 creator A5021489717 @default.
- W2034771653 creator A5030928088 @default.
- W2034771653 creator A5039455975 @default.
- W2034771653 creator A5080026444 @default.
- W2034771653 creator A5080149602 @default.
- W2034771653 date "2012-11-01" @default.
- W2034771653 modified "2023-10-17" @default.
- W2034771653 title "Differential gene expression in rainbow trout (Oncorhynchus mykiss) liver and ovary after exposure to zearalenone" @default.
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- W2034771653 doi "https://doi.org/10.1016/j.cbpc.2012.05.005" @default.
- W2034771653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22683937" @default.
- W2034771653 hasPublicationYear "2012" @default.
- W2034771653 type Work @default.