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• W2034771739 abstract "Objectives Sleep disorders, especially restless legs syndrome (RLS) and rapid eye movement sleep behavior disorder (RBD), are common in spinocerebellar ataxia type 3 or Machado–Joseph disease (MJD), and a possible underlying dopaminergic dysfunction is implicated. This study assessed the relationship between sleep disorders in MJD and dopamine transporter (DAT) densities. Patients and methods Twenty-two patients with MJD and twenty healthy subjects were enrolled in this study. MJD patients underwent clinical sleep evaluation and polysomnography. SPECT with [99mTc]-TRODAT-1, was performed in all subjects. Results DAT densities were significantly reduced in MJD group when compared to controls. No significant correlation was found between DAT densities and RLS or RBD in MJD. Conclusion Our study failed to demonstrate a clear correlation between sleep disorders and DAT densities in MJD patients, hence suggesting that extrastriatal and non-presynaptic dopamine pathways could be implicated in MJD-related sleep disorders." @default.
• W2034771739 created "2016-06-24" @default.
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• W2034771739 date "2013-01-01" @default.
• W2034771739 modified "2023-10-01" @default.
• W2034771739 title "Sleep disorders in Machado–Joseph disease: A dopamine transporter imaging study" @default.
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• W2034771739 doi "https://doi.org/10.1016/j.jns.2012.10.008" @default.
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