FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034772885> ?p ?o ?g. }

• W2034772885 endingPage "2419" @default.
• W2034772885 startingPage "2412" @default.
• W2034772885 abstract "Adipose tissue‐derived stem cells offer tremendous potential for regenerative medicine. However, characterization of their self‐renewal ability has not been performed yet, although it is a crucial feature for in vitro expansion of undifferentiated cells and in vivo maintenance of stem cell pools. We have undertaken the identification of molecular events that are involved in in vitro self‐renewal of human multipotent adipose‐derived stem (hMADS) cells from young donors, by assessing their proliferation rate, their ability to grow at the single‐cell level (clonogenicity), and their differentiation potential. As hMADS cells are propagated in culture, cell morphology changes dramatically, concomitantly to a progressive decrease in proliferation, clonogenicity, and differentiation potential. This decrease is associated with a decrease in fibroblast growth factor 2 (FGF2) expression and can be circumvented by chronic treatment with exogenous FGF2. Moreover, analysis of FGF2 secretion revealed that it is exported to hMADS cell surface without being released into the culture medium, suggesting a strictly autocrine loop. Indeed, treatment of FGF2‐expressing hMADS cells with PD173074, a specific FGF receptor inhibitor, decreases dramatically their clonogenicity and differentiation potential. Thus, hMADS cells express a functional autocrine FGF loop that allows maintenance of their self‐renewal ability in vitro. Finally, inhibition of mitogen‐activated protein kinase kinase 1 reduces the clonogenic potential of hMADS cells but does not affect their differentiation potential, indicating that the extracellular signal‐related kinases 1/2 signaling pathway is partly involved in FGF2‐mediated self‐renewal. Together, our data clearly identify the key function of FGF2 in the maintenance of self‐renewal of adipose tissue‐derived stem cells." @default.
• W2034772885 created "2016-06-24" @default.
• W2034772885 creator A5045163678 @default.
• W2034772885 creator A5046692579 @default.
• W2034772885 creator A5084915485 @default.
• W2034772885 date "2006-11-01" @default.
• W2034772885 modified "2023-10-02" @default.
• W2034772885 title "Autocrine Fibroblast Growth Factor 2 Signaling Is Critical for Self‐Renewal of Human Multipotent Adipose‐Derived Stem Cells" @default.
• W2034772885 cites W1501596399 @default.
• W2034772885 cites W1963550744 @default.
• W2034772885 cites W1965823380 @default.
• W2034772885 cites W1967632729 @default.
• W2034772885 cites W1970590929 @default.
• W2034772885 cites W1981478386 @default.
• W2034772885 cites W1986230815 @default.
• W2034772885 cites W1986656552 @default.
• W2034772885 cites W1987803647 @default.
• W2034772885 cites W1991162692 @default.
• W2034772885 cites W2001661745 @default.
• W2034772885 cites W2002777360 @default.
• W2034772885 cites W2005111784 @default.
• W2034772885 cites W2010066949 @default.
• W2034772885 cites W2013095857 @default.
• W2034772885 cites W2035690311 @default.
• W2034772885 cites W2038926374 @default.
• W2034772885 cites W2039877779 @default.
• W2034772885 cites W2045456080 @default.
• W2034772885 cites W2047998363 @default.
• W2034772885 cites W2049555359 @default.
• W2034772885 cites W2052767351 @default.
• W2034772885 cites W2053547368 @default.
• W2034772885 cites W2055759147 @default.
• W2034772885 cites W2058902172 @default.
• W2034772885 cites W2078035943 @default.
• W2034772885 cites W2081304354 @default.
• W2034772885 cites W2087124418 @default.
• W2034772885 cites W2089726534 @default.
• W2034772885 cites W2096221523 @default.
• W2034772885 cites W2103054294 @default.
• W2034772885 cites W2107503723 @default.
• W2034772885 cites W2110301828 @default.
• W2034772885 cites W2115675418 @default.
• W2034772885 cites W2119859961 @default.
• W2034772885 cites W2121878535 @default.
• W2034772885 cites W2122892477 @default.
• W2034772885 cites W2124318512 @default.
• W2034772885 cites W2125916510 @default.
• W2034772885 cites W2128040025 @default.
• W2034772885 cites W2135166835 @default.
• W2034772885 cites W2135711029 @default.
• W2034772885 cites W2137276142 @default.
• W2034772885 cites W2138178479 @default.
• W2034772885 cites W2143516374 @default.
• W2034772885 cites W2144268541 @default.
• W2034772885 cites W2150163104 @default.
• W2034772885 cites W2155533012 @default.
• W2034772885 cites W2161392800 @default.
• W2034772885 cites W2163102268 @default.
• W2034772885 cites W2167091901 @default.
• W2034772885 cites W2169529166 @default.
• W2034772885 cites W2170134994 @default.
• W2034772885 cites W3143191778 @default.
• W2034772885 doi "https://doi.org/10.1634/stemcells.2006-0006" @default.
• W2034772885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16840552" @default.
• W2034772885 hasPublicationYear "2006" @default.
• W2034772885 type Work @default.
• W2034772885 sameAs 2034772885 @default.
• W2034772885 citedByCount "230" @default.
• W2034772885 countsByYear W20347728852012 @default.
• W2034772885 countsByYear W20347728852013 @default.
• W2034772885 countsByYear W20347728852014 @default.
• W2034772885 countsByYear W20347728852015 @default.
• W2034772885 countsByYear W20347728852016 @default.
• W2034772885 countsByYear W20347728852017 @default.
• W2034772885 countsByYear W20347728852018 @default.
• W2034772885 countsByYear W20347728852019 @default.
• W2034772885 countsByYear W20347728852020 @default.
• W2034772885 countsByYear W20347728852021 @default.
• W2034772885 countsByYear W20347728852022 @default.
• W2034772885 countsByYear W20347728852023 @default.
• W2034772885 crossrefType "journal-article" @default.
• W2034772885 hasAuthorship W2034772885A5045163678 @default.
• W2034772885 hasAuthorship W2034772885A5046692579 @default.
• W2034772885 hasAuthorship W2034772885A5084915485 @default.
• W2034772885 hasConcept C104317684 @default.
• W2034772885 hasConcept C117262875 @default.
• W2034772885 hasConcept C128240485 @default.
• W2034772885 hasConcept C148738053 @default.
• W2034772885 hasConcept C1491633281 @default.
• W2034772885 hasConcept C170493617 @default.
• W2034772885 hasConcept C201750760 @default.
• W2034772885 hasConcept C28328180 @default.
• W2034772885 hasConcept C2910776680 @default.
• W2034772885 hasConcept C54355233 @default.
• W2034772885 hasConcept C55493867 @default.
• W2034772885 hasConcept C74373430 @default.
• W2034772885 hasConcept C7876069 @default.
• W2034772885 hasConcept C81885089 @default.

• next