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• W2034774009 startingPage "61" @default.
• W2034774009 abstract "A coplanar polychlorinated biphenyl (PCB) when eaten by test animals increased the rate of recombination in somatic cells, indicating a new mechanism of action for these compounds. Using the eye-mosaic test a high bioactivation strain of Drosophila that consumed 4,4′-dichlorobiphenyl (4,4′-DCB) manifested a genotoxicity rate that was three-fold greater than that in animals fed the solvent-spiked medium. This compound was not genotoxic in a suppressed bioactivation strain indicating that genotoxicity requires bioactivation of the compound. High bioactivation test strains made heterozygous for a paracentric inversion, a chromosomal rearrangement that suppresses homologous recombination, exhibited significantly reduced genotoxicity after treatment." @default.
• W2034774009 created "2016-06-24" @default.
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• W2034774009 date "1995-03-01" @default.
• W2034774009 modified "2023-10-18" @default.
• W2034774009 title "Genotoxicity of polychlorinated biphenyls (PCBs): recombinogenesis by biotransformation products" @default.
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• W2034774009 doi "https://doi.org/10.1016/0165-1218(95)90090-x" @default.
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