FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034774705> ?p ?o ?g. }

• W2034774705 endingPage "21" @default.
• W2034774705 startingPage "12" @default.
• W2034774705 abstract "Human drug use involves repeated choices to take drugs or to engage in alternative behaviors. The purpose of this study was to examine how response cost for cocaine and the value of an alternative reinforcer (opportunity to play a game of chance) and how ‘free’ doses (with minimal response cost) affected cocaine choice. Two laboratory studies of cocaine self-administration were conducted in a group of humans who were habitual cocaine smokers and in a group of rhesus monkeys that intravenously self-administered cocaine. Nine human cocaine smokers who were not seeking treatment for their cocaine were repeatedly presented with the choice to smoke 25 mg cocaine base or play a game of chance for a monetary bonus paid at study completion. The response cost for choosing cocaine varied (up to 4000 responses/dose) and the number of game plays varied (up to 8). In this sample of humans, increasing either the response cost for cocaine or increasing the value of the alternative reinforcer did not significantly affect cocaine choice, while increasing both simultaneously slightly decreased cocaine choice and increased choice of the alternative. In monkeys, the dose–response function for cocaine self-administration (10 choices of 0.0125–0.1 mg/kg/infusion vs. candy coated chocolate) was steep and we failed to achieve a 50/50 cocaine/candy choice even after substantially manipulating cost and number of candies available. Providing a large ‘free’ self-administered cocaine dose to humans did not significantly affect cocaine choice, whereas in monkeys, a large free dose of cocaine decreased cocaine choice when higher doses of cocaine were available for self-administration. The present results demonstrate that in the laboratory, it is difficult to modify on-going cocaine self-administration behavior in both humans and non-human primates." @default.
• W2034774705 created "2016-06-24" @default.
• W2034774705 creator A5023998451 @default.
• W2034774705 creator A5041943763 @default.
• W2034774705 creator A5054102952 @default.
• W2034774705 creator A5056961169 @default.
• W2034774705 creator A5068068755 @default.
• W2034774705 creator A5086691231 @default.
• W2034774705 creator A5088269697 @default.
• W2034774705 date "2015-07-01" @default.
• W2034774705 modified "2023-10-02" @default.
• W2034774705 title "Development of translational preclinical models in substance abuse: Effects of cocaine administration on cocaine choice in humans and non-human primates" @default.
• W2034774705 cites W1587254283 @default.
• W2034774705 cites W1823260965 @default.
• W2034774705 cites W1968909467 @default.
• W2034774705 cites W1978686840 @default.
• W2034774705 cites W1980402702 @default.
• W2034774705 cites W1985777444 @default.
• W2034774705 cites W1986287138 @default.
• W2034774705 cites W1987710197 @default.
• W2034774705 cites W2003472840 @default.
• W2034774705 cites W2007495472 @default.
• W2034774705 cites W2010185204 @default.
• W2034774705 cites W2015722751 @default.
• W2034774705 cites W2032755153 @default.
• W2034774705 cites W2035677168 @default.
• W2034774705 cites W2040903782 @default.
• W2034774705 cites W2041147149 @default.
• W2034774705 cites W2041644734 @default.
• W2034774705 cites W2046505018 @default.
• W2034774705 cites W2047831967 @default.
• W2034774705 cites W2049342626 @default.
• W2034774705 cites W2055296946 @default.
• W2034774705 cites W2058284686 @default.
• W2034774705 cites W2059119976 @default.
• W2034774705 cites W2059538444 @default.
• W2034774705 cites W2063933554 @default.
• W2034774705 cites W2068585026 @default.
• W2034774705 cites W2076221487 @default.
• W2034774705 cites W2076231598 @default.
• W2034774705 cites W2084485648 @default.
• W2034774705 cites W2092408072 @default.
• W2034774705 cites W2108878668 @default.
• W2034774705 cites W2116435594 @default.
• W2034774705 cites W2130241045 @default.
• W2034774705 cites W2131780481 @default.
• W2034774705 cites W2132542307 @default.
• W2034774705 cites W2134842419 @default.
• W2034774705 cites W2135588856 @default.
• W2034774705 cites W2169035832 @default.
• W2034774705 cites W238676633 @default.
• W2034774705 cites W2412335574 @default.
• W2034774705 doi "https://doi.org/10.1016/j.pbb.2015.03.023" @default.
• W2034774705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5846106" @default.
• W2034774705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25933796" @default.
• W2034774705 hasPublicationYear "2015" @default.
• W2034774705 type Work @default.
• W2034774705 sameAs 2034774705 @default.
• W2034774705 citedByCount "27" @default.
• W2034774705 countsByYear W20347747052015 @default.
• W2034774705 countsByYear W20347747052016 @default.
• W2034774705 countsByYear W20347747052017 @default.
• W2034774705 countsByYear W20347747052018 @default.
• W2034774705 countsByYear W20347747052019 @default.
• W2034774705 countsByYear W20347747052020 @default.
• W2034774705 countsByYear W20347747052021 @default.
• W2034774705 countsByYear W20347747052022 @default.
• W2034774705 crossrefType "journal-article" @default.
• W2034774705 hasAuthorship W2034774705A5023998451 @default.
• W2034774705 hasAuthorship W2034774705A5041943763 @default.
• W2034774705 hasAuthorship W2034774705A5054102952 @default.
• W2034774705 hasAuthorship W2034774705A5056961169 @default.
• W2034774705 hasAuthorship W2034774705A5068068755 @default.
• W2034774705 hasAuthorship W2034774705A5086691231 @default.
• W2034774705 hasAuthorship W2034774705A5088269697 @default.
• W2034774705 hasBestOaLocation W20347747052 @default.
• W2034774705 hasConcept C118552586 @default.
• W2034774705 hasConcept C15744967 @default.
• W2034774705 hasConcept C2776035688 @default.
• W2034774705 hasConcept C2778555786 @default.
• W2034774705 hasConcept C2910455596 @default.
• W2034774705 hasConcept C3020194580 @default.
• W2034774705 hasConcept C40010229 @default.
• W2034774705 hasConcept C42219234 @default.
• W2034774705 hasConcept C46312422 @default.
• W2034774705 hasConcept C67203356 @default.
• W2034774705 hasConcept C71924100 @default.
• W2034774705 hasConcept C77805123 @default.
• W2034774705 hasConcept C98274493 @default.
• W2034774705 hasConceptScore W2034774705C118552586 @default.
• W2034774705 hasConceptScore W2034774705C15744967 @default.
• W2034774705 hasConceptScore W2034774705C2776035688 @default.
• W2034774705 hasConceptScore W2034774705C2778555786 @default.
• W2034774705 hasConceptScore W2034774705C2910455596 @default.
• W2034774705 hasConceptScore W2034774705C3020194580 @default.
• W2034774705 hasConceptScore W2034774705C40010229 @default.
• W2034774705 hasConceptScore W2034774705C42219234 @default.
• W2034774705 hasConceptScore W2034774705C46312422 @default.

• next