FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034774815> ?p ?o ?g. }

• W2034774815 endingPage "519" @default.
• W2034774815 startingPage "509" @default.
• W2034774815 abstract "Thyroglobulin is the precursor of the thyroid hormones, triiodothyronine and thyroxine. Because the molecular size of thyroglobulin is relatively large (660 kDa), it could have other additional functions besides serving as the precursor of the thyroid hormones. In this report, we examined the proliferative effects of thyroglobulins purified from bovine and porcine thyroid tissues on the growth of a rat thyroid follicular cell line, FRTL-5, as well as the primary culture of porcine thyroid epithelial cells. Bovine and porcine thyroglobulins stimulated the proliferation of not only FRTL-5 cells but also porcine thyroid epithelial cells in a dose-dependent manner. The proliferative effect of thyroglobulin was neutralized by an anti-thyroglobulin monoclonal antibody but not by two different anti-fibroblast growth factor antibodies. The stimulatory signal of thyroglobulin was transmitted via the phosphatidylinositol 3-kinase pathway. Also, removal of the N-linked oligosaccharides on thyroglobulin reduced the proliferative activity of porcine thyroglobulin, suggesting that the proliferative effect of thyroglobulin is in part exerted by its carbohydrate moiety. Taken together, we have demonstrated for the first time that thyroglobulin possesses proliferative effect on thyroid epithelial cells in addition to being the precursor of the thyroid hormones." @default.
• W2034774815 created "2016-06-24" @default.
• W2034774815 creator A5029803988 @default.
• W2034774815 creator A5034396795 @default.
• W2034774815 creator A5045599016 @default.
• W2034774815 creator A5055696100 @default.
• W2034774815 creator A5057817047 @default.
• W2034774815 creator A5068935750 @default.
• W2034774815 date "2009-01-01" @default.
• W2034774815 modified "2023-09-26" @default.
• W2034774815 title "Proliferative Effects of Bovine and Porcine Thyroglobulins on Thyroid Epithelial Cells" @default.
• W2034774815 cites W1964495303 @default.
• W2034774815 cites W1964878444 @default.
• W2034774815 cites W1981510235 @default.
• W2034774815 cites W1986236392 @default.
• W2034774815 cites W1987900732 @default.
• W2034774815 cites W1992404212 @default.
• W2034774815 cites W1994127735 @default.
• W2034774815 cites W2004297890 @default.
• W2034774815 cites W2004579046 @default.
• W2034774815 cites W2010121064 @default.
• W2034774815 cites W2027503216 @default.
• W2034774815 cites W2028107559 @default.
• W2034774815 cites W2035110250 @default.
• W2034774815 cites W2039205571 @default.
• W2034774815 cites W2052749822 @default.
• W2034774815 cites W2055656914 @default.
• W2034774815 cites W2072037206 @default.
• W2034774815 cites W2073726892 @default.
• W2034774815 cites W2073732510 @default.
• W2034774815 cites W2078919738 @default.
• W2034774815 cites W2089714235 @default.
• W2034774815 cites W2096387860 @default.
• W2034774815 cites W2106196985 @default.
• W2034774815 cites W2125153669 @default.
• W2034774815 cites W2127405054 @default.
• W2034774815 cites W2129349637 @default.
• W2034774815 cites W2130329013 @default.
• W2034774815 cites W2137194057 @default.
• W2034774815 cites W2153509164 @default.
• W2034774815 cites W2164660404 @default.
• W2034774815 cites W2166902633 @default.
• W2034774815 cites W2314472510 @default.
• W2034774815 doi "https://doi.org/10.1507/endocrj.k08e-345" @default.
• W2034774815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19261995" @default.
• W2034774815 hasPublicationYear "2009" @default.
• W2034774815 type Work @default.
• W2034774815 sameAs 2034774815 @default.
• W2034774815 citedByCount "5" @default.
• W2034774815 countsByYear W20347748152012 @default.
• W2034774815 countsByYear W20347748152013 @default.
• W2034774815 countsByYear W20347748152017 @default.
• W2034774815 crossrefType "journal-article" @default.
• W2034774815 hasAuthorship W2034774815A5029803988 @default.
• W2034774815 hasAuthorship W2034774815A5034396795 @default.
• W2034774815 hasAuthorship W2034774815A5045599016 @default.
• W2034774815 hasAuthorship W2034774815A5055696100 @default.
• W2034774815 hasAuthorship W2034774815A5057817047 @default.
• W2034774815 hasAuthorship W2034774815A5068935750 @default.
• W2034774815 hasBestOaLocation W20347748151 @default.
• W2034774815 hasConcept C126322002 @default.
• W2034774815 hasConcept C134018914 @default.
• W2034774815 hasConcept C159654299 @default.
• W2034774815 hasConcept C185592680 @default.
• W2034774815 hasConcept C203014093 @default.
• W2034774815 hasConcept C2778057883 @default.
• W2034774815 hasConcept C2778835679 @default.
• W2034774815 hasConcept C526584372 @default.
• W2034774815 hasConcept C542903549 @default.
• W2034774815 hasConcept C54355233 @default.
• W2034774815 hasConcept C71315377 @default.
• W2034774815 hasConcept C71924100 @default.
• W2034774815 hasConcept C81885089 @default.
• W2034774815 hasConcept C86803240 @default.
• W2034774815 hasConceptScore W2034774815C126322002 @default.
• W2034774815 hasConceptScore W2034774815C134018914 @default.
• W2034774815 hasConceptScore W2034774815C159654299 @default.
• W2034774815 hasConceptScore W2034774815C185592680 @default.
• W2034774815 hasConceptScore W2034774815C203014093 @default.
• W2034774815 hasConceptScore W2034774815C2778057883 @default.
• W2034774815 hasConceptScore W2034774815C2778835679 @default.
• W2034774815 hasConceptScore W2034774815C526584372 @default.
• W2034774815 hasConceptScore W2034774815C542903549 @default.
• W2034774815 hasConceptScore W2034774815C54355233 @default.
• W2034774815 hasConceptScore W2034774815C71315377 @default.
• W2034774815 hasConceptScore W2034774815C71924100 @default.
• W2034774815 hasConceptScore W2034774815C81885089 @default.
• W2034774815 hasConceptScore W2034774815C86803240 @default.
• W2034774815 hasIssue "3" @default.
• W2034774815 hasLocation W20347748151 @default.
• W2034774815 hasLocation W20347748152 @default.
• W2034774815 hasOpenAccess W2034774815 @default.
• W2034774815 hasPrimaryLocation W20347748151 @default.
• W2034774815 hasRelatedWork W1972113515 @default.
• W2034774815 hasRelatedWork W2010645160 @default.
• W2034774815 hasRelatedWork W2026117978 @default.
• W2034774815 hasRelatedWork W2027938488 @default.
• W2034774815 hasRelatedWork W2074577918 @default.

• next