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- W2034774984 abstract "Enteropathogenic Escherichia coli (EPEC) are Gram (−) bacteria responsible for widespread illness in the form of diarrhea. EPEC cells attach to the intestinal epithelium using a Type III secretion system common to many Gram (−) bacteria. The translocated intimin receptor (TIR) is the first protein secreted through the EPEC secretion complex, and is absolutely required for pathogenesis. It inserts into the intestinal epithelium, serving as an anchor responsible for the attachment of EPEC to the host epithelial cell. Intimin is a transmembrane protein displayed on the EPEC cell surface with an extracellular domain that binds TIR. Observation of a TIR–TIR dimer in the X-ray co-crystal structure of the extracellular domains of intimin and TIR raised the question of how these protein domains interact and function in solution. Herein we report that the extracellular domain of TIR exists in a folded and active monomeric state in solution, as confirmed by analytical ultracentrifugation, analytical size-exclusion HPLC, isothermal titration calorimetry, and surface plasmon resonance." @default.
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- W2034774984 date "2007-11-01" @default.
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- W2034774984 title "Biophysical analysis of the EPEC translocated intimin receptor-binding domain" @default.
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- W2034774984 doi "https://doi.org/10.1016/j.bbrc.2007.08.123" @default.
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