Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034776152> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2034776152 endingPage "155A" @default.
- W2034776152 startingPage "155A" @default.
- W2034776152 abstract "In the fetal sheep, lactate is an important metabolic substrate and previous studies have shown placental lactate production and lactate uptake by the fetal liver. In the neonatal sheep, there is no placental lactate source and blood lactate concentrations are lower than in the fetus. To compare the importance of lactate as a substrate for fetal and neonatal liver metabolism, we measured lactate flux across the liver in 16 fetal sheep (mean gestational age 129 days) which had catheters chronically placed in the right or left hepatic vein, portal vein, descending aorta and umbilical vein and in 5 neonatal sheep (mean age 9 days) with similar catheters except for the umbilical vein. In addition, we measured umbilical lactate uptake in the fetal sheep. In the fetus, net hepatic lactate uptake was 5.0 mg/min/100 g. There was a linear correlation between hepatic and umbilical lactate uptake (r = 0.74, p < .005); hepatic uptake could account for nearly 90% of umbilical uptake, but hepatic lactate extraction was only 7.7% of hepatic lactate delivery (94.2 mg/min/100 g). In the neonate, net hepatic lactate uptake was more than twice the fetal rate (11.0 mg/min/100 g) and hepatic lactate extraction was 32.9% of hepatic lactate delivery (31.0 mg/min/100 g). Lactate is therefore an important substrate for both fetal and neonatal liver metabolism. Although lactate delivery to the neonatal liver decreases, increased hepatic extraction compensates so that hepatic lactate uptake actually increases. (Supported by HL24056.)" @default.
- W2034776152 created "2016-06-24" @default.
- W2034776152 creator A5001139539 @default.
- W2034776152 creator A5026580954 @default.
- W2034776152 creator A5051018722 @default.
- W2034776152 creator A5054537151 @default.
- W2034776152 creator A5071807376 @default.
- W2034776152 date "1985-04-01" @default.
- W2034776152 modified "2023-10-17" @default.
- W2034776152 title "268 LACTATE UPTAKE BY THE FETAL AND NEONATAL SHEEP LIVER" @default.
- W2034776152 doi "https://doi.org/10.1203/00006450-198504000-00298" @default.
- W2034776152 hasPublicationYear "1985" @default.
- W2034776152 type Work @default.
- W2034776152 sameAs 2034776152 @default.
- W2034776152 citedByCount "1" @default.
- W2034776152 countsByYear W20347761522018 @default.
- W2034776152 crossrefType "journal-article" @default.
- W2034776152 hasAuthorship W2034776152A5001139539 @default.
- W2034776152 hasAuthorship W2034776152A5026580954 @default.
- W2034776152 hasAuthorship W2034776152A5051018722 @default.
- W2034776152 hasAuthorship W2034776152A5054537151 @default.
- W2034776152 hasAuthorship W2034776152A5071807376 @default.
- W2034776152 hasBestOaLocation W20347761521 @default.
- W2034776152 hasConcept C126322002 @default.
- W2034776152 hasConcept C134018914 @default.
- W2034776152 hasConcept C16685009 @default.
- W2034776152 hasConcept C172680121 @default.
- W2034776152 hasConcept C202751555 @default.
- W2034776152 hasConcept C2777202286 @default.
- W2034776152 hasConcept C2777411675 @default.
- W2034776152 hasConcept C2778376644 @default.
- W2034776152 hasConcept C2779234561 @default.
- W2034776152 hasConcept C54355233 @default.
- W2034776152 hasConcept C55493867 @default.
- W2034776152 hasConcept C62231903 @default.
- W2034776152 hasConcept C71924100 @default.
- W2034776152 hasConcept C86803240 @default.
- W2034776152 hasConceptScore W2034776152C126322002 @default.
- W2034776152 hasConceptScore W2034776152C134018914 @default.
- W2034776152 hasConceptScore W2034776152C16685009 @default.
- W2034776152 hasConceptScore W2034776152C172680121 @default.
- W2034776152 hasConceptScore W2034776152C202751555 @default.
- W2034776152 hasConceptScore W2034776152C2777202286 @default.
- W2034776152 hasConceptScore W2034776152C2777411675 @default.
- W2034776152 hasConceptScore W2034776152C2778376644 @default.
- W2034776152 hasConceptScore W2034776152C2779234561 @default.
- W2034776152 hasConceptScore W2034776152C54355233 @default.
- W2034776152 hasConceptScore W2034776152C55493867 @default.
- W2034776152 hasConceptScore W2034776152C62231903 @default.
- W2034776152 hasConceptScore W2034776152C71924100 @default.
- W2034776152 hasConceptScore W2034776152C86803240 @default.
- W2034776152 hasIssue "4" @default.
- W2034776152 hasLocation W20347761521 @default.
- W2034776152 hasOpenAccess W2034776152 @default.
- W2034776152 hasPrimaryLocation W20347761521 @default.
- W2034776152 hasRelatedWork W1993795923 @default.
- W2034776152 hasRelatedWork W2002562299 @default.
- W2034776152 hasRelatedWork W2045448786 @default.
- W2034776152 hasRelatedWork W2064276263 @default.
- W2034776152 hasRelatedWork W2094857026 @default.
- W2034776152 hasRelatedWork W2095329316 @default.
- W2034776152 hasRelatedWork W2099734673 @default.
- W2034776152 hasRelatedWork W2141521254 @default.
- W2034776152 hasRelatedWork W2392339125 @default.
- W2034776152 hasRelatedWork W2156499933 @default.
- W2034776152 hasVolume "19" @default.
- W2034776152 isParatext "false" @default.
- W2034776152 isRetracted "false" @default.
- W2034776152 magId "2034776152" @default.
- W2034776152 workType "article" @default.