FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034776505> ?p ?o ?g. }

• W2034776505 endingPage "1418" @default.
• W2034776505 startingPage "1405" @default.
• W2034776505 abstract "Abstract The ATP‐dependent transporter ABCG2 exports certain photosensitizers (PS) from cells, implying that the enhanced expression of ABCG2 by cancer cells may confer resistance to photodynamic therapy (PDT) mediated by those PS. In 35 patient‐derived primary cultures of lung epithelial and stromal cells, PS with different subcellular localization and affinity for ABCG2 displayed cell‐type specific retention both independent and dependent on ABCG2. In the majority of cases, the ABCG2 substrate 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a (HPPH) was lost from fibroblastic cells more rapidly than from their epithelial counterparts, even in the absence of detectable ABCG2 expression, facilitating selective eradication by PDT of epithelial over fibroblastic cells in tumor/stroma co‐cultures. Pairwise comparison of normal and transformed epithelial cells also identified tumor cells with elevated or reduced retention of HPPH, depending on ABCG2. Enhanced ABCG2 expression led to the selective PDT survival of tumor cells in tumor/stroma co‐cultures. This survival pattern was reversible through HPPH derivatives that are not ABCG2 substrates or the ABCG2 inhibitor imatinib mesylate. PS retention, not differences in subcellular distribution or cell signaling responses, was determining cell type selective death by PDT. These data suggest that up‐front knowledge of tumor characteristics, specifically ABCG2 status, could be helpful in individualized PDT treatment design." @default.
• W2034776505 created "2016-06-24" @default.
• W2034776505 creator A5000953691 @default.
• W2034776505 creator A5006921382 @default.
• W2034776505 creator A5015979891 @default.
• W2034776505 creator A5033429257 @default.
• W2034776505 creator A5035386967 @default.
• W2034776505 date "2011-10-03" @default.
• W2034776505 modified "2023-10-16" @default.
• W2034776505 title "Cell-type Selective Phototoxicity Achieved with Chlorophyll-a Derived Photosensitizers in a Co-culture System of Primary Human Tumor and Normal Lung Cells" @default.
• W2034776505 cites W1576694604 @default.
• W2034776505 cites W1916661321 @default.
• W2034776505 cites W1967585504 @default.
• W2034776505 cites W1967759358 @default.
• W2034776505 cites W1967859455 @default.
• W2034776505 cites W1969092519 @default.
• W2034776505 cites W1970451833 @default.
• W2034776505 cites W1971379334 @default.
• W2034776505 cites W1972964752 @default.
• W2034776505 cites W1979901607 @default.
• W2034776505 cites W1985858988 @default.
• W2034776505 cites W1988022838 @default.
• W2034776505 cites W2004161136 @default.
• W2034776505 cites W2012699085 @default.
• W2034776505 cites W2015704490 @default.
• W2034776505 cites W2018692167 @default.
• W2034776505 cites W2019772485 @default.
• W2034776505 cites W2024214621 @default.
• W2034776505 cites W2030904862 @default.
• W2034776505 cites W2032626826 @default.
• W2034776505 cites W2043480572 @default.
• W2034776505 cites W2061910554 @default.
• W2034776505 cites W2082557022 @default.
• W2034776505 cites W2099519224 @default.
• W2034776505 cites W2108899627 @default.
• W2034776505 cites W2111501137 @default.
• W2034776505 cites W2114571271 @default.
• W2034776505 cites W2114669343 @default.
• W2034776505 cites W2122126311 @default.
• W2034776505 cites W2122245635 @default.
• W2034776505 cites W2129476795 @default.
• W2034776505 cites W2136656762 @default.
• W2034776505 cites W2136871762 @default.
• W2034776505 cites W2138436464 @default.
• W2034776505 cites W2145213448 @default.
• W2034776505 cites W2145682522 @default.
• W2034776505 cites W2147445587 @default.
• W2034776505 cites W2151734986 @default.
• W2034776505 cites W2152269992 @default.
• W2034776505 cites W2155011725 @default.
• W2034776505 cites W2158621547 @default.
• W2034776505 cites W2159724629 @default.
• W2034776505 cites W2161632561 @default.
• W2034776505 cites W2168833294 @default.
• W2034776505 cites W2170632492 @default.
• W2034776505 cites W2188149910 @default.
• W2034776505 doi "https://doi.org/10.1111/j.1751-1097.2011.00992.x" @default.
• W2034776505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3200467" @default.
• W2034776505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21883244" @default.
• W2034776505 hasPublicationYear "2011" @default.
• W2034776505 type Work @default.
• W2034776505 sameAs 2034776505 @default.
• W2034776505 citedByCount "27" @default.
• W2034776505 countsByYear W20347765052012 @default.
• W2034776505 countsByYear W20347765052013 @default.
• W2034776505 countsByYear W20347765052014 @default.
• W2034776505 countsByYear W20347765052015 @default.
• W2034776505 countsByYear W20347765052016 @default.
• W2034776505 countsByYear W20347765052017 @default.
• W2034776505 countsByYear W20347765052018 @default.
• W2034776505 countsByYear W20347765052019 @default.
• W2034776505 countsByYear W20347765052020 @default.
• W2034776505 countsByYear W20347765052021 @default.
• W2034776505 countsByYear W20347765052022 @default.
• W2034776505 countsByYear W20347765052023 @default.
• W2034776505 crossrefType "journal-article" @default.
• W2034776505 hasAuthorship W2034776505A5000953691 @default.
• W2034776505 hasAuthorship W2034776505A5006921382 @default.
• W2034776505 hasAuthorship W2034776505A5015979891 @default.
• W2034776505 hasAuthorship W2034776505A5033429257 @default.
• W2034776505 hasAuthorship W2034776505A5035386967 @default.
• W2034776505 hasBestOaLocation W20347765052 @default.
• W2034776505 hasConcept C104317684 @default.
• W2034776505 hasConcept C149011108 @default.
• W2034776505 hasConcept C1491633281 @default.
• W2034776505 hasConcept C153911025 @default.
• W2034776505 hasConcept C16930146 @default.
• W2034776505 hasConcept C178790620 @default.
• W2034776505 hasConcept C185592680 @default.
• W2034776505 hasConcept C2781323092 @default.
• W2034776505 hasConcept C44312359 @default.
• W2034776505 hasConcept C502942594 @default.
• W2034776505 hasConcept C512196 @default.
• W2034776505 hasConcept C54355233 @default.
• W2034776505 hasConcept C55493867 @default.
• W2034776505 hasConcept C81885089 @default.
• W2034776505 hasConcept C86803240 @default.
• W2034776505 hasConceptScore W2034776505C104317684 @default.

• next