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• W2034776993 abstract "Scope Maslinic acid is a bioactive minor component of Olea europaea L. with health‐enhancing activities and no harmful effects. A pharmacokinetic (PK) study was conducted to determine its bioavailability for future studies of maslinic acid in humans. Methods and results Intravenous (1 mg/kg) and oral (50 mg/kg) administrations to Sprague‐Dawley rats were performed. Blood was obtained several times over 24 h and PKs were analyzed with NONMEM 7.2, applying a population approach. Body weight was included a priori in the model with fixed allometric exponents, based on allometric principles. Plasma concentrations versus time were best characterized by a two‐open compartment model with first‐order absorption and linear elimination. Maslinic acid had a relative rapid oral absorption with a peak concentration after administration at 0.51 h and a bioavailability of 5.13%. Once in bloodstream, it distributed extensively into tissues, since the central and peripheral distribution volumes were 8.41 L/70 kg and 63.6 L/70 kg, respectively. The clearance (8 L/h/70 kg) was related to unaltered renal excretion. The prediction‐corrected visual predictive check confirmed its stability and predictive ability. Conclusion An allometric population PK model was performed for maslinic acid, which adequately described and predicted plasma concentrations." @default.
• W2034776993 created "2016-06-24" @default.
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• W2034776993 date "2014-08-22" @default.
• W2034776993 modified "2023-10-18" @default.
• W2034776993 title "Population pharmacokinetics of maslinic acid, a triterpene from olives, after intravenous and oral administration in rats" @default.
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• W2034776993 doi "https://doi.org/10.1002/mnfr.201400147" @default.
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