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- W2034777286 startingPage "1377" @default.
- W2034777286 abstract "Lipid A and its two chemically stable analogues, wherein the glycosidic phosphoryl groups in lipid A is replaced with 2-(phosphonooxy)ethyl or carboxymethyl groups, have been synthesized by an improved and divergent route via a common allyl glycoside intermediate in which the 4-hydroxy group was protected as a benzyl ether. The total yields were more than 20% for 11 or 12 steps starting from allyl 4,6-O-benzylidene-2-deoxy-2-(trichloroethoxycarbonylamino)-D-glucopyranoside. These synthetic chemically stable analogues induce interleukin-6 and tumor necrosis factor α in human peripheral whole blood cells with potencies comparable to those by natural-type synthetic lipid A. The Limulus activities of both analogues were found to be even stronger than the activity of the natural-type one." @default.
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- W2034777286 date "1999-06-01" @default.
- W2034777286 modified "2023-10-09" @default.
- W2034777286 title "A Divergent Synthesis of Lipid A and Its Chemically Stable Unnatural Analogues" @default.
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- W2034777286 doi "https://doi.org/10.1246/bcsj.72.1377" @default.
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