Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034779933> ?p ?o ?g. }
- W2034779933 endingPage "928" @default.
- W2034779933 startingPage "915" @default.
- W2034779933 abstract "TGFbeta signaling controls diverse normal developmental processes and pathogenesis of diseases including cancer and autoimmune and fibrotic diseases. TGFbeta responses are generally mediated through transcriptional functions of Smads. A key step in TGFbeta signaling is ligand-induced phosphorylation of receptor-activated Smads (R-Smads) catalyzed by the TGFbeta type I receptor kinase. However, the potential of Smad dephosphorylation as a regulatory mechanism of TGFbeta signaling and the identity of Smad-specific phosphatases remain elusive. Using a functional genomic approach, we have identified PPM1A/PP2Calpha as a bona fide Smad phosphatase. PPM1A dephosphorylates and promotes nuclear export of TGFbeta-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFbeta-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFbeta signaling in mammalian cells. Smad-antagonizing activity of PPM1A is also observed during Nodal-dependent early embryogenesis in zebrafish. This work demonstrates that PPM1A/PP2Calpha, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling." @default.
- W2034779933 created "2016-06-24" @default.
- W2034779933 creator A5011318452 @default.
- W2034779933 creator A5013727947 @default.
- W2034779933 creator A5017945055 @default.
- W2034779933 creator A5018181452 @default.
- W2034779933 creator A5031050602 @default.
- W2034779933 creator A5038650712 @default.
- W2034779933 creator A5048362732 @default.
- W2034779933 creator A5055740291 @default.
- W2034779933 creator A5058936244 @default.
- W2034779933 creator A5071644380 @default.
- W2034779933 creator A5074675103 @default.
- W2034779933 creator A5089024133 @default.
- W2034779933 creator A5090080418 @default.
- W2034779933 creator A5091493201 @default.
- W2034779933 date "2006-06-01" @default.
- W2034779933 modified "2023-10-18" @default.
- W2034779933 title "PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling" @default.
- W2034779933 cites W1550903947 @default.
- W2034779933 cites W1585156891 @default.
- W2034779933 cites W1595294734 @default.
- W2034779933 cites W1966615054 @default.
- W2034779933 cites W1973047647 @default.
- W2034779933 cites W1977341692 @default.
- W2034779933 cites W1978146894 @default.
- W2034779933 cites W1982351482 @default.
- W2034779933 cites W1984086000 @default.
- W2034779933 cites W1988298690 @default.
- W2034779933 cites W1997780033 @default.
- W2034779933 cites W2000497765 @default.
- W2034779933 cites W2001355136 @default.
- W2034779933 cites W2003907692 @default.
- W2034779933 cites W2007620508 @default.
- W2034779933 cites W2016872220 @default.
- W2034779933 cites W2017201371 @default.
- W2034779933 cites W2017761226 @default.
- W2034779933 cites W2017800749 @default.
- W2034779933 cites W2018649316 @default.
- W2034779933 cites W2021484300 @default.
- W2034779933 cites W2034662853 @default.
- W2034779933 cites W2035653659 @default.
- W2034779933 cites W2036349827 @default.
- W2034779933 cites W2048355846 @default.
- W2034779933 cites W2064870799 @default.
- W2034779933 cites W2069414088 @default.
- W2034779933 cites W2069526853 @default.
- W2034779933 cites W2073264990 @default.
- W2034779933 cites W2082867992 @default.
- W2034779933 cites W2082873063 @default.
- W2034779933 cites W2083513032 @default.
- W2034779933 cites W2086692663 @default.
- W2034779933 cites W2094280155 @default.
- W2034779933 cites W2095762981 @default.
- W2034779933 cites W2104570676 @default.
- W2034779933 cites W2109635867 @default.
- W2034779933 cites W2111786431 @default.
- W2034779933 cites W2116217777 @default.
- W2034779933 cites W2117200840 @default.
- W2034779933 cites W2117814548 @default.
- W2034779933 cites W2135175655 @default.
- W2034779933 cites W2138852914 @default.
- W2034779933 cites W2141047192 @default.
- W2034779933 cites W2143714027 @default.
- W2034779933 cites W2162937786 @default.
- W2034779933 cites W2164615751 @default.
- W2034779933 cites W2171078009 @default.
- W2034779933 cites W2426574755 @default.
- W2034779933 doi "https://doi.org/10.1016/j.cell.2006.03.044" @default.
- W2034779933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6309366" @default.
- W2034779933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27610577" @default.
- W2034779933 hasPublicationYear "2006" @default.
- W2034779933 type Work @default.
- W2034779933 sameAs 2034779933 @default.
- W2034779933 citedByCount "431" @default.
- W2034779933 countsByYear W20347799332012 @default.
- W2034779933 countsByYear W20347799332013 @default.
- W2034779933 countsByYear W20347799332014 @default.
- W2034779933 countsByYear W20347799332015 @default.
- W2034779933 countsByYear W20347799332016 @default.
- W2034779933 countsByYear W20347799332017 @default.
- W2034779933 countsByYear W20347799332018 @default.
- W2034779933 countsByYear W20347799332019 @default.
- W2034779933 countsByYear W20347799332020 @default.
- W2034779933 countsByYear W20347799332021 @default.
- W2034779933 countsByYear W20347799332022 @default.
- W2034779933 countsByYear W20347799332023 @default.
- W2034779933 crossrefType "journal-article" @default.
- W2034779933 hasAuthorship W2034779933A5011318452 @default.
- W2034779933 hasAuthorship W2034779933A5013727947 @default.
- W2034779933 hasAuthorship W2034779933A5017945055 @default.
- W2034779933 hasAuthorship W2034779933A5018181452 @default.
- W2034779933 hasAuthorship W2034779933A5031050602 @default.
- W2034779933 hasAuthorship W2034779933A5038650712 @default.
- W2034779933 hasAuthorship W2034779933A5048362732 @default.
- W2034779933 hasAuthorship W2034779933A5055740291 @default.
- W2034779933 hasAuthorship W2034779933A5058936244 @default.
- W2034779933 hasAuthorship W2034779933A5071644380 @default.