FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034780169> ?p ?o ?g. }

• W2034780169 endingPage "F732" @default.
• W2034780169 startingPage "F723" @default.
• W2034780169 abstract "The limited antifibrotic effect of therapeutic angiotensin blockade, the fact that angiotensin blockade dramatically elevates renin levels, and recent evidence that renin has an angiotensin-independent, receptor-mediated profibrotic action led us to hypothesize that combining renin receptor inhibition and ANG II blockade would increase the antifibrotic effect of angiotensin blockade alone. Using cultured nephritic glomeruli from rats with anti-Thy-1-induced glomerulonephritis, the maximally effective dose of enalaprilate was determined to be 10(-4) M, which reduced mRNAs for transforming growth factor (TGF)-β1, fibronectin (FN), and plasminogen activator inhibitor-1 (PAI-1) by 49, 65, and 56% and production of TGF-β1 and FN proteins by 60 and 49%, respectively. Disease alone caused 6.8-fold increases in ANG II levels that were reduced 64% with enalaprilate. In contrast, two- and threefold disease-induced increases in renin mRNA and activity were further increased 2- and 3.7-fold with 10(-4) M enalaprilate treatment. Depressing the renin receptor by 80% with small interfering (si) RNA alone reduced fibrotic markers in a manner remarkably similar to enalaprilate alone but had no effect on glomerular renin expression. Enalaprilate and siRNA combination therapy further reduced disease markers. Notably, elevated TGF-β1 and FN production was reduced by 73 and 81%, respectively. These results support the notion of a receptor-mediated profibrotic action of renin, suggest that the limited effectiveness of ANG II blockade may be due, at least in part, to the elevated renin they induce, and support our hypothesis that adding renin receptor inhibitor to ANG II blockade in patients may have therapeutic potential." @default.
• W2034780169 created "2016-06-24" @default.
• W2034780169 creator A5010680177 @default.
• W2034780169 creator A5030509416 @default.
• W2034780169 creator A5037282171 @default.
• W2034780169 creator A5072858878 @default.
• W2034780169 creator A5089850418 @default.
• W2034780169 date "2011-10-01" @default.
• W2034780169 modified "2023-10-16" @default.
• W2034780169 title "Combining angiotensin II blockade and renin receptor inhibition results in enhanced antifibrotic effect in experimental nephritis" @default.
• W2034780169 cites W1967839067 @default.
• W2034780169 cites W1975211903 @default.
• W2034780169 cites W1977675408 @default.
• W2034780169 cites W1978818371 @default.
• W2034780169 cites W1998122147 @default.
• W2034780169 cites W2012034969 @default.
• W2034780169 cites W2019310839 @default.
• W2034780169 cites W2022848846 @default.
• W2034780169 cites W2022858571 @default.
• W2034780169 cites W2038800901 @default.
• W2034780169 cites W2046233066 @default.
• W2034780169 cites W2048698207 @default.
• W2034780169 cites W2049491194 @default.
• W2034780169 cites W2060335268 @default.
• W2034780169 cites W2066538838 @default.
• W2034780169 cites W2070820122 @default.
• W2034780169 cites W2076433252 @default.
• W2034780169 cites W2084040603 @default.
• W2034780169 cites W2084305905 @default.
• W2034780169 cites W2084324116 @default.
• W2034780169 cites W2101895473 @default.
• W2034780169 cites W2110538950 @default.
• W2034780169 cites W2117258523 @default.
• W2034780169 cites W2118152677 @default.
• W2034780169 cites W2119056313 @default.
• W2034780169 cites W2125298036 @default.
• W2034780169 cites W2127043863 @default.
• W2034780169 cites W2128520582 @default.
• W2034780169 cites W2129554934 @default.
• W2034780169 cites W2134800982 @default.
• W2034780169 cites W2135439806 @default.
• W2034780169 cites W2146227799 @default.
• W2034780169 cites W2146559746 @default.
• W2034780169 cites W2148200469 @default.
• W2034780169 cites W2150582820 @default.
• W2034780169 cites W2151295696 @default.
• W2034780169 cites W2157304932 @default.
• W2034780169 cites W2166710642 @default.
• W2034780169 cites W2170415924 @default.
• W2034780169 cites W2171818587 @default.
• W2034780169 cites W217459427 @default.
• W2034780169 cites W2241455767 @default.
• W2034780169 cites W2267181675 @default.
• W2034780169 cites W2287862640 @default.
• W2034780169 cites W2315796856 @default.
• W2034780169 cites W2396625216 @default.
• W2034780169 cites W2407958861 @default.
• W2034780169 cites W2414678281 @default.
• W2034780169 cites W4252006013 @default.
• W2034780169 cites W4252397535 @default.
• W2034780169 cites W1600158523 @default.
• W2034780169 doi "https://doi.org/10.1152/ajprenal.00271.2011" @default.
• W2034780169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191801" @default.
• W2034780169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21795644" @default.
• W2034780169 hasPublicationYear "2011" @default.
• W2034780169 type Work @default.
• W2034780169 sameAs 2034780169 @default.
• W2034780169 citedByCount "25" @default.
• W2034780169 countsByYear W20347801692012 @default.
• W2034780169 countsByYear W20347801692013 @default.
• W2034780169 countsByYear W20347801692014 @default.
• W2034780169 countsByYear W20347801692015 @default.
• W2034780169 countsByYear W20347801692016 @default.
• W2034780169 countsByYear W20347801692017 @default.
• W2034780169 countsByYear W20347801692018 @default.
• W2034780169 countsByYear W20347801692019 @default.
• W2034780169 countsByYear W20347801692020 @default.
• W2034780169 countsByYear W20347801692022 @default.
• W2034780169 countsByYear W20347801692023 @default.
• W2034780169 crossrefType "journal-article" @default.
• W2034780169 hasAuthorship W2034780169A5010680177 @default.
• W2034780169 hasAuthorship W2034780169A5030509416 @default.
• W2034780169 hasAuthorship W2034780169A5037282171 @default.
• W2034780169 hasAuthorship W2034780169A5072858878 @default.
• W2034780169 hasAuthorship W2034780169A5089850418 @default.
• W2034780169 hasBestOaLocation W20347801692 @default.
• W2034780169 hasConcept C104849204 @default.
• W2034780169 hasConcept C126322002 @default.
• W2034780169 hasConcept C134018914 @default.
• W2034780169 hasConcept C170493617 @default.
• W2034780169 hasConcept C185592680 @default.
• W2034780169 hasConcept C198710026 @default.
• W2034780169 hasConcept C2778468042 @default.
• W2034780169 hasConcept C2908929049 @default.
• W2034780169 hasConcept C71924100 @default.
• W2034780169 hasConcept C84393581 @default.
• W2034780169 hasConcept C98274493 @default.
• W2034780169 hasConceptScore W2034780169C104849204 @default.

• next