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- W2034782402 endingPage "428" @default.
- W2034782402 startingPage "421" @default.
- W2034782402 abstract "The gastrointestinal adverse effects of nonsteroidal anti‐inflammatory drugs (NSAIDs) have been recognized since shortly after the introduction of aspirin to the marketplace over a century ago. However, the underlying pathogenesis of NSAID‐induced gastropathy remains incompletely understood. Advances in understanding some of the factors that contribute to the mucosal injury have provided clues for the development of safer NSAIDs. The inhibitory effects of nitric oxide (NO) on NSAID‐induced leukocyte adherence were exploited in the development of NO‐releasing NSAIDs. As well as eliciting less gastrointestinal damage than conventional NSAIDs, these drugs do not elevate blood pressure and show anti‐inflammatory effects, additional to those of the parent drugs. Modification of other drugs in a similar manner (i.e., NO‐releasing derivatives) has similarly resulted in more effective drugs. More recently, hydrogen sulphide‐releasing derivatives of NSAIDs and of other drugs, have been developed, based on the observed ability of H 2 S to reduce inflammation and pain in experimental models. H 2 S‐releasing NSAIDs produce negligible gastric damage and exhibit enhanced anti‐inflammatory potency as compared to the parent drugs. The NO‐NSAIDs and H 2 S‐releasing NSAIDs represent examples of new anti‐inflammatory drugs with greatly reduced toxicity and improved therapeutic activity, both created through the concept of exploiting the beneficial effects of endogenous gaseous mediators. British Journal of Pharmacology (2007) 152 , 421–428; doi: 10.1038/sj.bjp.0707396 ; published online 16 July 2007" @default.
- W2034782402 created "2016-06-24" @default.
- W2034782402 creator A5027937626 @default.
- W2034782402 date "2007-10-01" @default.
- W2034782402 modified "2023-10-13" @default.
- W2034782402 title "Building a better aspirin: gaseous solutions to a century-old problem" @default.
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