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- W2034783002 startingPage "357" @default.
- W2034783002 abstract "Hippo pathway, originally discovered in Drosophila, is responsible for organ size control. The pathway is conserved in mammals and has a significant role in restraining cancer development. Regulating the Hippo pathway thus represents a potential therapeutic approach to treat cancer, which however requires deep understanding of the targeted pathway. Despite our limited knowledge on the pathway, there are increasing discoveries of new molecules that regulate and modulate the Hippo downstream signaling particularly in various solid malignancies, from extracellular stimuli or via pathway crosstalk. Herein, we discuss the roles of newly identified and key regulators that connect with core components (MST1/2, LATS1/2, SAV1, and MOB1) and downstream effector (YAP) in the Hippo pathway having an important role in cancer development and progression. Understanding of the mammalian Hippo pathway regulation may shed new insights to allow us selecting the right oncogenic targets and designing effective drugs for cancer treatments." @default.
- W2034783002 created "2016-06-24" @default.
- W2034783002 creator A5004721191 @default.
- W2034783002 creator A5038698746 @default.
- W2034783002 creator A5058387925 @default.
- W2034783002 creator A5068265233 @default.
- W2034783002 creator A5089804910 @default.
- W2034783002 date "2012-12-01" @default.
- W2034783002 modified "2023-10-10" @default.
- W2034783002 title "Regulators of mammalian Hippo pathway in cancer" @default.
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