FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034783053> ?p ?o ?g. }

• W2034783053 endingPage "808" @default.
• W2034783053 startingPage "803" @default.
• W2034783053 abstract "The effects of several imidazole antimycotic agents, an imidazole and several mineralocorticoid analogs on the cytochrome P-450(11)beta-catalyzed 11 beta-hydroxylation of 11-deoxycorticosterone and aldosterone synthesis were examined. Ketoconazole, clotrimazole, miconazole and etomidate were found to be potent inhibitors of the reactions, causing 50% inhibition of the 11 beta-hydroxylase activity at concentrations between 10(-8) and 10(-7) M. The potency of etomidate as to the inhibition of aldosterone- and 18-hydroxycorticosterone-production was found to be almost equal to that in the case of 11 beta-hydroxylation. Spironolactone and other newly synthesized mineralocorticoid analogs were also found to inhibit the cytochrome P-450(11)beta-mediated reactions. The ID50 values of these drugs for inhibition of the 11 beta-hydroxylase activity were almost equal to those in the case of the aldosterone- and 18-hydroxycorticosterone-biosynthetic activities. The results of kinetical studies indicated that one of the mineralocorticoid analogs, Compound 23-0586, acts as a competitive inhibitor for the cytochrome P-450(11)beta-mediated reactions." @default.
• W2034783053 created "2016-06-24" @default.
• W2034783053 creator A5035657531 @default.
• W2034783053 creator A5042017809 @default.
• W2034783053 creator A5044706467 @default.
• W2034783053 creator A5075069044 @default.
• W2034783053 date "1988-11-01" @default.
• W2034783053 modified "2023-09-25" @default.
• W2034783053 title "Inhibition of bovine adrenocortical mitochondrial cytochrome P-45011β-mediated reactions by imidazole derivatives and mineralocorticoid analogs" @default.
• W2034783053 cites W1682948375 @default.
• W2034783053 cites W1900162889 @default.
• W2034783053 cites W1975533067 @default.
• W2034783053 cites W1990893435 @default.
• W2034783053 cites W1993116170 @default.
• W2034783053 cites W2007469254 @default.
• W2034783053 cites W2015285864 @default.
• W2034783053 cites W2033345598 @default.
• W2034783053 cites W2061801926 @default.
• W2034783053 cites W2076915947 @default.
• W2034783053 cites W2130792052 @default.
• W2034783053 cites W2344486695 @default.
• W2034783053 cites W299769444 @default.
• W2034783053 cites W4249240580 @default.
• W2034783053 cites W4372211933 @default.
• W2034783053 doi "https://doi.org/10.1016/0022-4731(88)90289-0" @default.
• W2034783053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3199819" @default.
• W2034783053 hasPublicationYear "1988" @default.
• W2034783053 type Work @default.
• W2034783053 sameAs 2034783053 @default.
• W2034783053 citedByCount "14" @default.
• W2034783053 countsByYear W20347830532017 @default.
• W2034783053 countsByYear W20347830532021 @default.
• W2034783053 crossrefType "journal-article" @default.
• W2034783053 hasAuthorship W2034783053A5035657531 @default.
• W2034783053 hasAuthorship W2034783053A5042017809 @default.
• W2034783053 hasAuthorship W2034783053A5044706467 @default.
• W2034783053 hasAuthorship W2034783053A5075069044 @default.
• W2034783053 hasConcept C126322002 @default.
• W2034783053 hasConcept C134018914 @default.
• W2034783053 hasConcept C181199279 @default.
• W2034783053 hasConcept C185592680 @default.
• W2034783053 hasConcept C198710026 @default.
• W2034783053 hasConcept C2776069600 @default.
• W2034783053 hasConcept C2776379505 @default.
• W2034783053 hasConcept C2777229883 @default.
• W2034783053 hasConcept C2778525890 @default.
• W2034783053 hasConcept C2779548794 @default.
• W2034783053 hasConcept C2780249997 @default.
• W2034783053 hasConcept C2780628323 @default.
• W2034783053 hasConcept C2780768313 @default.
• W2034783053 hasConcept C2780874372 @default.
• W2034783053 hasConcept C2780902042 @default.
• W2034783053 hasConcept C2781064554 @default.
• W2034783053 hasConcept C2781109383 @default.
• W2034783053 hasConcept C526171541 @default.
• W2034783053 hasConcept C55493867 @default.
• W2034783053 hasConcept C71240020 @default.
• W2034783053 hasConcept C71315377 @default.
• W2034783053 hasConcept C71924100 @default.
• W2034783053 hasConcept C84393581 @default.
• W2034783053 hasConcept C86803240 @default.
• W2034783053 hasConcept C89423630 @default.
• W2034783053 hasConcept C98274493 @default.
• W2034783053 hasConceptScore W2034783053C126322002 @default.
• W2034783053 hasConceptScore W2034783053C134018914 @default.
• W2034783053 hasConceptScore W2034783053C181199279 @default.
• W2034783053 hasConceptScore W2034783053C185592680 @default.
• W2034783053 hasConceptScore W2034783053C198710026 @default.
• W2034783053 hasConceptScore W2034783053C2776069600 @default.
• W2034783053 hasConceptScore W2034783053C2776379505 @default.
• W2034783053 hasConceptScore W2034783053C2777229883 @default.
• W2034783053 hasConceptScore W2034783053C2778525890 @default.
• W2034783053 hasConceptScore W2034783053C2779548794 @default.
• W2034783053 hasConceptScore W2034783053C2780249997 @default.
• W2034783053 hasConceptScore W2034783053C2780628323 @default.
• W2034783053 hasConceptScore W2034783053C2780768313 @default.
• W2034783053 hasConceptScore W2034783053C2780874372 @default.
• W2034783053 hasConceptScore W2034783053C2780902042 @default.
• W2034783053 hasConceptScore W2034783053C2781064554 @default.
• W2034783053 hasConceptScore W2034783053C2781109383 @default.
• W2034783053 hasConceptScore W2034783053C526171541 @default.
• W2034783053 hasConceptScore W2034783053C55493867 @default.
• W2034783053 hasConceptScore W2034783053C71240020 @default.
• W2034783053 hasConceptScore W2034783053C71315377 @default.
• W2034783053 hasConceptScore W2034783053C71924100 @default.
• W2034783053 hasConceptScore W2034783053C84393581 @default.
• W2034783053 hasConceptScore W2034783053C86803240 @default.
• W2034783053 hasConceptScore W2034783053C89423630 @default.
• W2034783053 hasConceptScore W2034783053C98274493 @default.
• W2034783053 hasIssue "5" @default.
• W2034783053 hasLocation W20347830531 @default.
• W2034783053 hasLocation W20347830532 @default.
• W2034783053 hasOpenAccess W2034783053 @default.
• W2034783053 hasPrimaryLocation W20347830531 @default.
• W2034783053 hasRelatedWork W1980583333 @default.
• W2034783053 hasRelatedWork W2034783053 @default.
• W2034783053 hasRelatedWork W2037408526 @default.
• W2034783053 hasRelatedWork W2101834938 @default.

• next