FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034783673> ?p ?o ?g. }

• W2034783673 endingPage "331" @default.
• W2034783673 startingPage "321" @default.
• W2034783673 abstract "1 Cerebellar granule neurons (CGNs) possess a standing outward potassium current (IK(SO)) which shares many similarities with current through the two-pore domain potassium channel TASK-1 and which is inhibited following activation of muscarinic acetylcholine receptors. 2 The action of muscarine on IK(SO) was unaffected by the M2 receptor antagonist methoctramine (100 nM) but was blocked by the M3 antagonist zamifenacin, which, at a concentration of 100 nM, shifted the muscarine concentration-response curve to the right by around 50-fold. 3 Surprisingly, M3 receptor activation rarely produced a detectable increase in [Ca2+]i unless preceded by depolarization of the cells with 25 mM K+. Experiments with thapsigargin and ionomycin suggested that the endoplasmic reticulum Ca2+ stores in CGNs were depleted at rest. In contrast, cerebellar glial cells in the same fields of cells possessed substantial endoplasmic reticulum Ca2+ stores at rest. 4 Pretreatment of the cells with BAPTA AM, thapsigargin or the phospholipase C (PLC) inhibitor U-73122 all blocked the muscarine-induced Ca2+ signal but had little or no effect on muscarinic inhibition of IK(SO). Raising [Ca2+]i directly with ionomycin caused a small but significant inhibition of IK(SO). 5 It is concluded that muscarine acts on M3 muscarinic acetylcholine receptors both to inhibit IK(SO) and to mobilize Ca2+ from intracellular stores in CGNs. While the mobilization of Ca2+ occurs through activation of PLC, this does not seem to be the primary mechanism underlying muscarinic inhibition of IK(SO)." @default.
• W2034783673 created "2016-06-24" @default.
• W2034783673 creator A5008058076 @default.
• W2034783673 creator A5014692107 @default.
• W2034783673 creator A5054144477 @default.
• W2034783673 creator A5057319119 @default.
• W2034783673 date "2000-12-01" @default.
• W2034783673 modified "2023-10-15" @default.
• W2034783673 title "The role of Ca²⁺ stores in the muscarinic inhibition of the K⁺ current <i>I</i>_K(SO) in neonatal rat cerebellar granule cells" @default.
• W2034783673 cites W1664352025 @default.
• W2034783673 cites W1934131103 @default.
• W2034783673 cites W1963631121 @default.
• W2034783673 cites W1972351611 @default.
• W2034783673 cites W1984633991 @default.
• W2034783673 cites W1987970152 @default.
• W2034783673 cites W1991262933 @default.
• W2034783673 cites W1993610211 @default.
• W2034783673 cites W1996024251 @default.
• W2034783673 cites W1997537641 @default.
• W2034783673 cites W1999788892 @default.
• W2034783673 cites W2001418258 @default.
• W2034783673 cites W2004851466 @default.
• W2034783673 cites W2005026579 @default.
• W2034783673 cites W2006355149 @default.
• W2034783673 cites W2017694567 @default.
• W2034783673 cites W2021039431 @default.
• W2034783673 cites W2023939748 @default.
• W2034783673 cites W2026409252 @default.
• W2034783673 cites W2027617326 @default.
• W2034783673 cites W2029470479 @default.
• W2034783673 cites W2030195151 @default.
• W2034783673 cites W2036923572 @default.
• W2034783673 cites W2038867232 @default.
• W2034783673 cites W2041690080 @default.
• W2034783673 cites W2042007534 @default.
• W2034783673 cites W2044408699 @default.
• W2034783673 cites W2048352597 @default.
• W2034783673 cites W2056056096 @default.
• W2034783673 cites W2060257987 @default.
• W2034783673 cites W2066008360 @default.
• W2034783673 cites W2070832223 @default.
• W2034783673 cites W2073653273 @default.
• W2034783673 cites W2079928956 @default.
• W2034783673 cites W2088093088 @default.
• W2034783673 cites W2096437759 @default.
• W2034783673 cites W2107882590 @default.
• W2034783673 cites W2113630547 @default.
• W2034783673 cites W2115117267 @default.
• W2034783673 cites W2115353492 @default.
• W2034783673 cites W2134182782 @default.
• W2034783673 cites W2137046511 @default.
• W2034783673 cites W2141260882 @default.
• W2034783673 cites W2164458919 @default.
• W2034783673 cites W2169518110 @default.
• W2034783673 cites W2170912183 @default.
• W2034783673 cites W4210976202 @default.
• W2034783673 doi "https://doi.org/10.1111/j.1469-7793.2000.00321.x" @default.
• W2034783673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2270195" @default.
• W2034783673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11101643" @default.
• W2034783673 hasPublicationYear "2000" @default.
• W2034783673 type Work @default.
• W2034783673 sameAs 2034783673 @default.
• W2034783673 citedByCount "37" @default.
• W2034783673 countsByYear W20347836732012 @default.
• W2034783673 countsByYear W20347836732014 @default.
• W2034783673 countsByYear W20347836732019 @default.
• W2034783673 crossrefType "journal-article" @default.
• W2034783673 hasAuthorship W2034783673A5008058076 @default.
• W2034783673 hasAuthorship W2034783673A5014692107 @default.
• W2034783673 hasAuthorship W2034783673A5054144477 @default.
• W2034783673 hasAuthorship W2034783673A5057319119 @default.
• W2034783673 hasBestOaLocation W20347836732 @default.
• W2034783673 hasConcept C116289061 @default.
• W2034783673 hasConcept C12554922 @default.
• W2034783673 hasConcept C126322002 @default.
• W2034783673 hasConcept C134018914 @default.
• W2034783673 hasConcept C158617107 @default.
• W2034783673 hasConcept C170493617 @default.
• W2034783673 hasConcept C185592680 @default.
• W2034783673 hasConcept C2775910092 @default.
• W2034783673 hasConcept C2776961477 @default.
• W2034783673 hasConcept C2776989580 @default.
• W2034783673 hasConcept C2777146706 @default.
• W2034783673 hasConcept C2778597717 @default.
• W2034783673 hasConcept C2778824757 @default.
• W2034783673 hasConcept C2778988552 @default.
• W2034783673 hasConcept C2779600325 @default.
• W2034783673 hasConcept C2780841807 @default.
• W2034783673 hasConcept C33789571 @default.
• W2034783673 hasConcept C4141045 @default.
• W2034783673 hasConcept C55493867 @default.
• W2034783673 hasConcept C71924100 @default.
• W2034783673 hasConcept C79879829 @default.
• W2034783673 hasConcept C86803240 @default.
• W2034783673 hasConcept C95444343 @default.
• W2034783673 hasConceptScore W2034783673C116289061 @default.
• W2034783673 hasConceptScore W2034783673C12554922 @default.
• W2034783673 hasConceptScore W2034783673C126322002 @default.

• next