FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034783882> ?p ?o ?g. }

• W2034783882 endingPage "683" @default.
• W2034783882 startingPage "679" @default.
• W2034783882 abstract "Aliskiren represents the first member in a new class of antihypertensive drugs. Inhibiting the renin-angiotensin system at its rate-limiting step is an idea that has been pursued for >30 years; however, earlier compounds failed because of problems related to efficacy, bioavailability, and/or side effects. Aliskiren, a 610 Da nonpeptide molecule, has exceptional affinity for the human renin enzymatic site and a half-life of about 40 h, which make its 3% bioavailability clinically unimportant with continued administration. The drug is not metabolized by CYP P450 enzymes and is excreted >90% unchanged by the fecal route. No adjustments are necessary for renal function, liver function, age, ethnicity, or other prescribed drugs. Blood pressure reductions are similar to those provided by other monotherapies. Interestingly, aliskiren combined with angiotensin receptor blocker or angiotensin-converting enzyme inhibitor therapy leads to a further blood pressure reduction as does combination with a diuretic or calcium channel blocker. The fact that plasma renin activity is reduced to low levels with aliskiren could provide a theoretical advantage over other treatments, while increases in total renin (prorenin) after the drug poses additional food for thought. Studies with primary cardiovascular and renal end points to address these possibilities are in progress." @default.
• W2034783882 created "2016-06-24" @default.
• W2034783882 creator A5008146428 @default.
• W2034783882 creator A5079089312 @default.
• W2034783882 date "2008-03-01" @default.
• W2034783882 modified "2023-10-04" @default.
• W2034783882 title "Antihypertensive therapy with aliskiren" @default.
• W2034783882 cites W103159710 @default.
• W2034783882 cites W1490285206 @default.
• W2034783882 cites W1909110915 @default.
• W2034783882 cites W1974608423 @default.
• W2034783882 cites W1977572412 @default.
• W2034783882 cites W1985025184 @default.
• W2034783882 cites W1989480555 @default.
• W2034783882 cites W1989720576 @default.
• W2034783882 cites W1990042304 @default.
• W2034783882 cites W1993114157 @default.
• W2034783882 cites W1999748957 @default.
• W2034783882 cites W2015569360 @default.
• W2034783882 cites W2016485702 @default.
• W2034783882 cites W2019310839 @default.
• W2034783882 cites W2021198354 @default.
• W2034783882 cites W2026232111 @default.
• W2034783882 cites W2027617419 @default.
• W2034783882 cites W2039201409 @default.
• W2034783882 cites W2039432504 @default.
• W2034783882 cites W2039908249 @default.
• W2034783882 cites W2051665025 @default.
• W2034783882 cites W2055420779 @default.
• W2034783882 cites W2083898560 @default.
• W2034783882 cites W2097760859 @default.
• W2034783882 cites W2101668704 @default.
• W2034783882 cites W2103803344 @default.
• W2034783882 cites W2106182986 @default.
• W2034783882 cites W2115479774 @default.
• W2034783882 cites W2120723151 @default.
• W2034783882 cites W2121213050 @default.
• W2034783882 cites W2127790911 @default.
• W2034783882 cites W2128343930 @default.
• W2034783882 cites W2132234966 @default.
• W2034783882 cites W2133558239 @default.
• W2034783882 cites W2145461177 @default.
• W2034783882 cites W2146227799 @default.
• W2034783882 cites W2148232557 @default.
• W2034783882 cites W2153396732 @default.
• W2034783882 cites W2166710642 @default.
• W2034783882 cites W2166819422 @default.
• W2034783882 cites W2171818587 @default.
• W2034783882 cites W2313231090 @default.
• W2034783882 cites W2323202113 @default.
• W2034783882 doi "https://doi.org/10.1038/sj.ki.5002732" @default.
• W2034783882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18160962" @default.
• W2034783882 hasPublicationYear "2008" @default.
• W2034783882 type Work @default.
• W2034783882 sameAs 2034783882 @default.
• W2034783882 citedByCount "28" @default.
• W2034783882 countsByYear W20347838822012 @default.
• W2034783882 countsByYear W20347838822013 @default.
• W2034783882 countsByYear W20347838822014 @default.
• W2034783882 countsByYear W20347838822017 @default.
• W2034783882 countsByYear W20347838822022 @default.
• W2034783882 crossrefType "journal-article" @default.
• W2034783882 hasAuthorship W2034783882A5008146428 @default.
• W2034783882 hasAuthorship W2034783882A5079089312 @default.
• W2034783882 hasBestOaLocation W20347838821 @default.
• W2034783882 hasConcept C126322002 @default.
• W2034783882 hasConcept C134018914 @default.
• W2034783882 hasConcept C138976137 @default.
• W2034783882 hasConcept C181389837 @default.
• W2034783882 hasConcept C198710026 @default.
• W2034783882 hasConcept C2777425892 @default.
• W2034783882 hasConcept C2779838083 @default.
• W2034783882 hasConcept C2779918671 @default.
• W2034783882 hasConcept C2780035454 @default.
• W2034783882 hasConcept C71924100 @default.
• W2034783882 hasConcept C84393581 @default.
• W2034783882 hasConcept C98274493 @default.
• W2034783882 hasConceptScore W2034783882C126322002 @default.
• W2034783882 hasConceptScore W2034783882C134018914 @default.
• W2034783882 hasConceptScore W2034783882C138976137 @default.
• W2034783882 hasConceptScore W2034783882C181389837 @default.
• W2034783882 hasConceptScore W2034783882C198710026 @default.
• W2034783882 hasConceptScore W2034783882C2777425892 @default.
• W2034783882 hasConceptScore W2034783882C2779838083 @default.
• W2034783882 hasConceptScore W2034783882C2779918671 @default.
• W2034783882 hasConceptScore W2034783882C2780035454 @default.
• W2034783882 hasConceptScore W2034783882C71924100 @default.
• W2034783882 hasConceptScore W2034783882C84393581 @default.
• W2034783882 hasConceptScore W2034783882C98274493 @default.
• W2034783882 hasIssue "6" @default.
• W2034783882 hasLocation W20347838821 @default.
• W2034783882 hasLocation W20347838822 @default.
• W2034783882 hasOpenAccess W2034783882 @default.
• W2034783882 hasPrimaryLocation W20347838821 @default.
• W2034783882 hasRelatedWork W1977123261 @default.
• W2034783882 hasRelatedWork W2044747643 @default.
• W2034783882 hasRelatedWork W2076433252 @default.
• W2034783882 hasRelatedWork W2077998387 @default.

• next