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- W2034784178 abstract "Recent results from basic and translational research on tumor genesis and progression establish the basis for future therapeutic approaches. Targeted therapeutics are tailored toward the molecular abnormalities that cause tumor progression and could potentially provide an effective, non-toxic therapeutic approach in a broad range of cancers including melanoma. Cancer is as much a (cyto)genetic disease as it is an epigenetic disease. Indeed, the fate of the cell depends on a delicate balance between expression and repression of genes. The notion that drastic changes in DNA methylation and histone modifications are present in a variety of human tumors has prompted the development and characterization of epigenetic drugs. Inhibitors of histone deacetylases and methyltransferases as well as of the proteasome are covered in this review. Neue Erkenntnisse der Grundlagen und angewandten Forschung zu Fragen der Tumorentstehung und -progression bilden die Grundlage für moderne the-rapeutische Entwicklungen. Gezielte Therapeutika greifen maßgeschneidert in molekulare Veränderungen der Onkogenese ein und ermöglichen so eine effektive und dabei wenig toxische Therapie von Tumoren einschließlich des Melanoms. Tumore basieren sowohl auf (zyto)genetischen als auch auf epige-netischen Aberrationen. Das Schicksal einer Zelle beruht auf der feinen Balance von Expression und Repression von Genen. Die Beobachtung, dass in der Vielzahl von Tumoren dramatische Veränderungen der DNA-Methylierung oder der Histonacetylierung vorliegen, führte zur Entwicklung und Charakterisie-rung von Wirkstoffen, die diesen Umstand adressieren. Histondeacetylaseinhi-bitoren oder Hemmstoffe der DNA-Methylierung erlauben die Derepression von Tumorsuppressorgenen, während Proteasomeninhibitoren über eine verminderte Degradierung antitumoraler Proteine wirken. In der vorliegenden Übersicht sollen die theoretischen Grundlagen für diese neuen Therapie-ansätze dargelegt werden." @default.
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- W2034784178 date "2006-02-01" @default.
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- W2034784178 title "New therapeutic approaches for solid tumors: Histone deacetylase, methyltransferase and proteasome inhibitors" @default.
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- W2034784178 doi "https://doi.org/10.1111/j.1610-0387.2006.05920.x" @default.
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