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• W2034784505 endingPage "559" @default.
• W2034784505 startingPage "541" @default.
• W2034784505 abstract "T IE concepts and investigational technics of renal physiology which have proved so useful in elucidating the mechanisms by which various organic substances are excreted have not, to date, proven similarly effective in clarifying the processes by which the volume and electrolyte content of the body fluids are regulated. This is due, in part, to a difference in the nature of the information which is necessary for such an understanding. In many of the renal mechanisms which have been more or less adequately defined the functional role of the kidney has been either strictly excretory or adapted to conservation of the material concerned. In the case of sodium, potassium, chloride, bicarbonate and water the function of the kidneys is regulatory as well as excretory. Changes in excretion which are of insignificant proportions in the excretion of most other substances are the object of central interest in the renal control of water and the major electrolytes. Loss of 1 per cent of the glucose filtered at the glomeruli may be disregarded and tubular reabsorption under such circumstances considered to be “essentially complete.” Loss of an extra 1 per cent of the filtered sodium in a normal individual would correspond to an excess excretion of about 15 gm. of salt per day, an amount which cannot be regarded as insignificant. A satisfactory elucidation of the renal mechanisms for electrolyte excretion has lagged not only as a result of the necessity for taking into account small changes in rates of reabsorption and excretion, but also because of the complex interrelations involved between cations and anions, between different ions of similar charge and between water and electrolytes. A further difficulty is the multiplicity of factors involved in the control of the renal tubular transport of electrolytes and water. This discussion cannot purport to be a review of this extensive and complex subject. It is intended largely to indicate the many unsolved and intricate problems and to present some of the background against which work in the field must be considered." @default.
• W2034784505 created "2016-06-24" @default.
• W2034784505 creator A5051576258 @default.
• W2034784505 date "1950-10-01" @default.
• W2034784505 modified "2023-09-26" @default.
• W2034784505 title "Renal excretion of water, sodium, chloride, potassium, calcium and magnesium" @default.
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