FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034784666> ?p ?o ?g. }

• W2034784666 endingPage "1114" @default.
• W2034784666 startingPage "1107" @default.
• W2034784666 abstract "Spinal muscular atrophy (SMA) is characterized by degeneration of motor neurons of the spinal cord associated with muscle paralysis and caused by mutations of the survival motor neuron gene (SMN). To determine whether SMN gene defect in skeletal muscle might have a role in SMA pathogenesis, deletion of murine SMN exon 7, the most frequent mutation found in SMA, has been restricted to skeletal muscle by using the Cre-loxP system. Mutant mice display ongoing muscle necrosis with a dystrophic phenotype leading to muscle paralysis and death. The dystrophic phenotype is associated with elevated levels of creatine kinase activity, Evans blue dye uptake into muscle fibers, reduced amount of dystrophin and upregulation of utrophin expression suggesting a destabilization of the sarcolemma components. The mutant mice will be a valuable model for elucidating the underlying mechanism. Moreover, our results suggest a primary involvement of skeletal muscle in human SMA, which may contribute to motor defect in addition to muscle denervation caused by the motor neuron degeneration. These data may have important implications for the development of therapeutic strategies in SMA." @default.
• W2034784666 created "2016-06-24" @default.
• W2034784666 creator A5000999343 @default.
• W2034784666 creator A5004585962 @default.
• W2034784666 creator A5025337084 @default.
• W2034784666 creator A5044423436 @default.
• W2034784666 creator A5070438555 @default.
• W2034784666 creator A5082349643 @default.
• W2034784666 creator A5085871253 @default.
• W2034784666 creator A5087011929 @default.
• W2034784666 date "2001-03-05" @default.
• W2034784666 modified "2023-10-18" @default.
• W2034784666 title "Deletion of Murine <i>SMN</i> Exon 7 Directed to Skeletal Muscle Leads to Severe Muscular Dystrophy" @default.
• W2034784666 cites W1554872850 @default.
• W2034784666 cites W1586539673 @default.
• W2034784666 cites W1963985395 @default.
• W2034784666 cites W1967287827 @default.
• W2034784666 cites W1971572027 @default.
• W2034784666 cites W1978668631 @default.
• W2034784666 cites W1979437987 @default.
• W2034784666 cites W1980477780 @default.
• W2034784666 cites W1996412713 @default.
• W2034784666 cites W2004087787 @default.
• W2034784666 cites W2054669239 @default.
• W2034784666 cites W2067661389 @default.
• W2034784666 cites W2070936696 @default.
• W2034784666 cites W2072349055 @default.
• W2034784666 cites W2074697255 @default.
• W2034784666 cites W2082510094 @default.
• W2034784666 cites W2085465310 @default.
• W2034784666 cites W2117637570 @default.
• W2034784666 cites W2122329067 @default.
• W2034784666 cites W2129294012 @default.
• W2034784666 cites W2132519155 @default.
• W2034784666 cites W2139521871 @default.
• W2034784666 cites W2143513370 @default.
• W2034784666 cites W2152182259 @default.
• W2034784666 cites W2164418621 @default.
• W2034784666 doi "https://doi.org/10.1083/jcb.152.5.1107" @default.
• W2034784666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2198815" @default.
• W2034784666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11238465" @default.
• W2034784666 hasPublicationYear "2001" @default.
• W2034784666 type Work @default.
• W2034784666 sameAs 2034784666 @default.
• W2034784666 citedByCount "202" @default.
• W2034784666 countsByYear W20347846662012 @default.
• W2034784666 countsByYear W20347846662013 @default.
• W2034784666 countsByYear W20347846662014 @default.
• W2034784666 countsByYear W20347846662015 @default.
• W2034784666 countsByYear W20347846662016 @default.
• W2034784666 countsByYear W20347846662017 @default.
• W2034784666 countsByYear W20347846662018 @default.
• W2034784666 countsByYear W20347846662019 @default.
• W2034784666 countsByYear W20347846662020 @default.
• W2034784666 countsByYear W20347846662021 @default.
• W2034784666 countsByYear W20347846662022 @default.
• W2034784666 countsByYear W20347846662023 @default.
• W2034784666 crossrefType "journal-article" @default.
• W2034784666 hasAuthorship W2034784666A5000999343 @default.
• W2034784666 hasAuthorship W2034784666A5004585962 @default.
• W2034784666 hasAuthorship W2034784666A5025337084 @default.
• W2034784666 hasAuthorship W2034784666A5044423436 @default.
• W2034784666 hasAuthorship W2034784666A5070438555 @default.
• W2034784666 hasAuthorship W2034784666A5082349643 @default.
• W2034784666 hasAuthorship W2034784666A5085871253 @default.
• W2034784666 hasAuthorship W2034784666A5087011929 @default.
• W2034784666 hasBestOaLocation W20347846661 @default.
• W2034784666 hasConcept C104317684 @default.
• W2034784666 hasConcept C114614502 @default.
• W2034784666 hasConcept C127716648 @default.
• W2034784666 hasConcept C134018914 @default.
• W2034784666 hasConcept C161921814 @default.
• W2034784666 hasConcept C169760540 @default.
• W2034784666 hasConcept C181709278 @default.
• W2034784666 hasConcept C199096232 @default.
• W2034784666 hasConcept C2776752467 @default.
• W2034784666 hasConcept C2778558090 @default.
• W2034784666 hasConcept C2778649560 @default.
• W2034784666 hasConcept C2778943923 @default.
• W2034784666 hasConcept C2779030066 @default.
• W2034784666 hasConcept C2779959927 @default.
• W2034784666 hasConcept C2780394045 @default.
• W2034784666 hasConcept C2780775167 @default.
• W2034784666 hasConcept C33923547 @default.
• W2034784666 hasConcept C54355233 @default.
• W2034784666 hasConcept C78343239 @default.
• W2034784666 hasConcept C86803240 @default.
• W2034784666 hasConceptScore W2034784666C104317684 @default.
• W2034784666 hasConceptScore W2034784666C114614502 @default.
• W2034784666 hasConceptScore W2034784666C127716648 @default.
• W2034784666 hasConceptScore W2034784666C134018914 @default.
• W2034784666 hasConceptScore W2034784666C161921814 @default.
• W2034784666 hasConceptScore W2034784666C169760540 @default.
• W2034784666 hasConceptScore W2034784666C181709278 @default.
• W2034784666 hasConceptScore W2034784666C199096232 @default.
• W2034784666 hasConceptScore W2034784666C2776752467 @default.
• W2034784666 hasConceptScore W2034784666C2778558090 @default.
• W2034784666 hasConceptScore W2034784666C2778649560 @default.

• next