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• W2034784952 abstract "This study was designed to establish an interleukin-12 (IL-12)-expressing murine Lewis lung carcinoma (LLC) cell vaccine (LLC/murine IL-12 [mIL-12]) and assess its antitumor efficacy and mechanism in vivo. The recombinant IL-12 plasmid was transfected into LLC cells and screened by G418, and positive clones were obtained. C57BL/6 tumor-bearing mouse model was established and tumor-bearing mice were randomly divided into three groups (n = 20), that is, treated with an intratumoral injection of phosphate-buffered solution, blank plasmid, or LLC/mIL-12 vaccine, respectively, at days 0, 7, and 14. Tumor size was measured before and after treatment. Tumor growth curve was plotted, cytolytic T lymphocyte (CTL) activity assay and natural killer (NK) cell activity assay were performed, CD4+ and CD8+ T lymphocyte were quantitated using flow cytometry, and the expression of interferon-γ (IFN-γ), IL-12, and interferon-inducible protein-10 (IP-10) in serum was detected by ELISA. Microvessel density was determined by immunohistochemistry after all mice were euthanized at day 21. The study revealed suppressed tumor growth, elevated levels of IFN-γ, IP-10, and IL-12, augmented NK and CTL cell activities, and decreased microvessel density of tumor tissues. There were abundant CD4+ and CD8+ T lymphocyte infiltration in the vaccine group. This study demonstrated that the antitumor mechanism of LLC/mIL-12 vaccine was to promote IFN-γ and IL-12 secretion, augment the NK and CTL cell activities, and decrease the microvessel density of tumors." @default.
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• W2034784952 date "2010-06-01" @default.
• W2034784952 modified "2023-10-16" @default.
• W2034784952 title "AntiTumor Mechanism of Recombinant Murine Interleukin-12 Vaccine" @default.
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• W2034784952 doi "https://doi.org/10.1089/cbr.2010.0771" @default.
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