Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034785082> ?p ?o ?g. }
- W2034785082 endingPage "3300" @default.
- W2034785082 startingPage "3289" @default.
- W2034785082 abstract "SCO4008 from Streptomyces coelicolor A3(2) is a member of the TetR family. However, its precise function is not yet clear. In this study, the crystal structure of SCO4008 was determined at a resolution of 2.3Å, and its DNA-binding properties were analyzed. Crystal structure analysis showed that SCO4008 forms an Ω-shaped homodimer in which the monomer is composed of an N-terminal DNA-binding domain containing a helix-turn-helix and a C-terminal dimerization and regulatory domain possessing a ligand-binding cavity. The genomic systematic evolution of ligands by exponential enrichment and electrophoretic mobility shift assay revealed that four SCO4008 dimers bind to the two operator regions located between sco4008 and sco4007, a secondary transporter belonging to the major facilitator superfamily. Ligand screening analysis showed that SCO4008 recognizes a wide range of structurally dissimilar cationic and hydrophobic compounds. These results suggested that SCO4008 is a transcriptional repressor of sco4007 responsible for the multidrug resistance system in S. coelicolor A3(2)." @default.
- W2034785082 created "2016-06-24" @default.
- W2034785082 creator A5011170655 @default.
- W2034785082 creator A5020556619 @default.
- W2034785082 creator A5022233637 @default.
- W2034785082 creator A5027169862 @default.
- W2034785082 creator A5055196663 @default.
- W2034785082 creator A5059433035 @default.
- W2034785082 creator A5077307889 @default.
- W2034785082 creator A5085639432 @default.
- W2034785082 date "2013-09-01" @default.
- W2034785082 modified "2023-09-24" @default.
- W2034785082 title "SCO4008, a Putative TetR Transcriptional Repressor from Streptomyces coelicolor A3(2), Regulates Transcription of sco4007 by Multidrug Recognition" @default.
- W2034785082 cites W1539796472 @default.
- W2034785082 cites W1816644759 @default.
- W2034785082 cites W1964588409 @default.
- W2034785082 cites W1969156185 @default.
- W2034785082 cites W1983102771 @default.
- W2034785082 cites W1986191025 @default.
- W2034785082 cites W1993063963 @default.
- W2034785082 cites W1995017064 @default.
- W2034785082 cites W1996616414 @default.
- W2034785082 cites W2008343440 @default.
- W2034785082 cites W2012960603 @default.
- W2034785082 cites W2014264942 @default.
- W2034785082 cites W2015115438 @default.
- W2034785082 cites W2023790301 @default.
- W2034785082 cites W2025192657 @default.
- W2034785082 cites W2027397937 @default.
- W2034785082 cites W2031232438 @default.
- W2034785082 cites W2033506791 @default.
- W2034785082 cites W2040430892 @default.
- W2034785082 cites W2044337867 @default.
- W2034785082 cites W2052018677 @default.
- W2034785082 cites W2058357139 @default.
- W2034785082 cites W2062158257 @default.
- W2034785082 cites W2071416115 @default.
- W2034785082 cites W2076078575 @default.
- W2034785082 cites W2084045864 @default.
- W2034785082 cites W2102743211 @default.
- W2034785082 cites W2114886047 @default.
- W2034785082 cites W2130381741 @default.
- W2034785082 cites W2132717858 @default.
- W2034785082 cites W2138956992 @default.
- W2034785082 cites W2143694829 @default.
- W2034785082 cites W2144998676 @default.
- W2034785082 cites W2146725149 @default.
- W2034785082 cites W2149123067 @default.
- W2034785082 cites W2157298893 @default.
- W2034785082 cites W2157489482 @default.
- W2034785082 cites W2162097287 @default.
- W2034785082 cites W2171535756 @default.
- W2034785082 doi "https://doi.org/10.1016/j.jmb.2013.06.013" @default.
- W2034785082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23831227" @default.
- W2034785082 hasPublicationYear "2013" @default.
- W2034785082 type Work @default.
- W2034785082 sameAs 2034785082 @default.
- W2034785082 citedByCount "10" @default.
- W2034785082 countsByYear W20347850822013 @default.
- W2034785082 countsByYear W20347850822014 @default.
- W2034785082 countsByYear W20347850822015 @default.
- W2034785082 countsByYear W20347850822019 @default.
- W2034785082 countsByYear W20347850822021 @default.
- W2034785082 countsByYear W20347850822022 @default.
- W2034785082 crossrefType "journal-article" @default.
- W2034785082 hasAuthorship W2034785082A5011170655 @default.
- W2034785082 hasAuthorship W2034785082A5020556619 @default.
- W2034785082 hasAuthorship W2034785082A5022233637 @default.
- W2034785082 hasAuthorship W2034785082A5027169862 @default.
- W2034785082 hasAuthorship W2034785082A5055196663 @default.
- W2034785082 hasAuthorship W2034785082A5059433035 @default.
- W2034785082 hasAuthorship W2034785082A5077307889 @default.
- W2034785082 hasAuthorship W2034785082A5085639432 @default.
- W2034785082 hasConcept C104317684 @default.
- W2034785082 hasConcept C107824862 @default.
- W2034785082 hasConcept C138885662 @default.
- W2034785082 hasConcept C143065580 @default.
- W2034785082 hasConcept C149011108 @default.
- W2034785082 hasConcept C158448853 @default.
- W2034785082 hasConcept C179926584 @default.
- W2034785082 hasConcept C183978625 @default.
- W2034785082 hasConcept C185592680 @default.
- W2034785082 hasConcept C2777274385 @default.
- W2034785082 hasConcept C2780681812 @default.
- W2034785082 hasConcept C33987129 @default.
- W2034785082 hasConcept C41895202 @default.
- W2034785082 hasConcept C54355233 @default.
- W2034785082 hasConcept C552990157 @default.
- W2034785082 hasConcept C62465871 @default.
- W2034785082 hasConcept C86339819 @default.
- W2034785082 hasConcept C86803240 @default.
- W2034785082 hasConceptScore W2034785082C104317684 @default.
- W2034785082 hasConceptScore W2034785082C107824862 @default.
- W2034785082 hasConceptScore W2034785082C138885662 @default.
- W2034785082 hasConceptScore W2034785082C143065580 @default.
- W2034785082 hasConceptScore W2034785082C149011108 @default.
- W2034785082 hasConceptScore W2034785082C158448853 @default.
- W2034785082 hasConceptScore W2034785082C179926584 @default.