FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034785972> ?p ?o ?g. }

• W2034785972 abstract "Hypothalamic-pituitary-adrenocortical function in rats with brain lesions induced by neonatal monosodium glutamate (MSG) treatment (4 mg/g, 5 administrations, i.p.) was evaluated in the present study. Using in situ hybridization we found increased proopiomelanocortin (POMC) mRNA levels in the adenopituitary and normal corticotropin-releasing hormone mRNA levels in the hypothalamic paraventricular nucleus in MSG-treated rats. The total content of pituitary adrenocorticotropin (ACTH) was not changed, while pituitary ACTH concentration was higher in MSG-treated compared to control rats. The number of ACTH-immunostained cells per a constant area of adenohypophysial section, as measured by immunohistochemistry, was unchanged indicating that no significant condensation of corticotropes occurred. Basal plasma ACTH concentrations were not different, whereas morning corticosterone levels were elevated in rats with MSG treatment. While ACTH response to stress stimuli was similar in both groups of rats, corticosterone response to exogenous ACTH (500 ng/kg, i.v., Synacthen), short-lasting handling and immobilization was of the same magnitude but prolonged in MSG-treated rats. Based on the decline of [3H] corticosterone in plasma, a decreased corticosterone clearance rate was found in MSG-treated rats. These findings suggest that MSG treatment results in increased POMC gene expression per corticotrope of the atrophic pituitary resulting in maintenance of normal pituitary ACTH stores and plasma ACTH levels. Elevated basal levels of corticosterone in plasma as well as prolonged corticosterone responses to stimulations in rats treated with MSG seem to be due to a decreased clearance rate of corticosterone." @default.
• W2034785972 created "2016-06-24" @default.
• W2034785972 creator A5007965745 @default.
• W2034785972 creator A5014744969 @default.
• W2034785972 creator A5023082493 @default.
• W2034785972 date "1998-01-01" @default.
• W2034785972 modified "2023-10-14" @default.
• W2034785972 title "Neurotoxic Lesions Induced by Monosodium Glutamate Result in Increased Adenopituitary Proopiomelanocortin Gene Expression and Decreased Corticosterone Clearance in Rats" @default.
• W2034785972 cites W1606525067 @default.
• W2034785972 cites W1967417013 @default.
• W2034785972 cites W1978543866 @default.
• W2034785972 cites W1983035678 @default.
• W2034785972 cites W1983747837 @default.
• W2034785972 cites W1983897178 @default.
• W2034785972 cites W1985483609 @default.
• W2034785972 cites W2012757283 @default.
• W2034785972 cites W2015356716 @default.
• W2034785972 cites W2015736315 @default.
• W2034785972 cites W2028593366 @default.
• W2034785972 cites W2033678540 @default.
• W2034785972 cites W2034530295 @default.
• W2034785972 cites W2055758379 @default.
• W2034785972 cites W2061554433 @default.
• W2034785972 cites W2063584743 @default.
• W2034785972 cites W2064854929 @default.
• W2034785972 cites W2081658345 @default.
• W2034785972 cites W2084399430 @default.
• W2034785972 cites W2086596518 @default.
• W2034785972 cites W2088474335 @default.
• W2034785972 cites W2121663374 @default.
• W2034785972 cites W2176587065 @default.
• W2034785972 cites W2276613636 @default.
• W2034785972 cites W2400648882 @default.
• W2034785972 cites W2404716386 @default.
• W2034785972 cites W2414167367 @default.
• W2034785972 doi "https://doi.org/10.1159/000054340" @default.
• W2034785972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9662721" @default.
• W2034785972 hasPublicationYear "1998" @default.
• W2034785972 type Work @default.
• W2034785972 sameAs 2034785972 @default.
• W2034785972 citedByCount "34" @default.
• W2034785972 countsByYear W20347859722013 @default.
• W2034785972 countsByYear W20347859722015 @default.
• W2034785972 countsByYear W20347859722021 @default.
• W2034785972 crossrefType "journal-article" @default.
• W2034785972 hasAuthorship W2034785972A5007965745 @default.
• W2034785972 hasAuthorship W2034785972A5014744969 @default.
• W2034785972 hasAuthorship W2034785972A5023082493 @default.
• W2034785972 hasConcept C104317684 @default.
• W2034785972 hasConcept C126322002 @default.
• W2034785972 hasConcept C134018914 @default.
• W2034785972 hasConcept C150194340 @default.
• W2034785972 hasConcept C185592680 @default.
• W2034785972 hasConcept C2776989845 @default.
• W2034785972 hasConcept C2777003273 @default.
• W2034785972 hasConcept C2777658017 @default.
• W2034785972 hasConcept C2778024521 @default.
• W2034785972 hasConcept C2779306644 @default.
• W2034785972 hasConcept C2780352252 @default.
• W2034785972 hasConcept C2780546910 @default.
• W2034785972 hasConcept C2781309135 @default.
• W2034785972 hasConcept C55493867 @default.
• W2034785972 hasConcept C71315377 @default.
• W2034785972 hasConcept C71924100 @default.
• W2034785972 hasConcept C79381400 @default.
• W2034785972 hasConcept C81439078 @default.
• W2034785972 hasConcept C86803240 @default.
• W2034785972 hasConceptScore W2034785972C104317684 @default.
• W2034785972 hasConceptScore W2034785972C126322002 @default.
• W2034785972 hasConceptScore W2034785972C134018914 @default.
• W2034785972 hasConceptScore W2034785972C150194340 @default.
• W2034785972 hasConceptScore W2034785972C185592680 @default.
• W2034785972 hasConceptScore W2034785972C2776989845 @default.
• W2034785972 hasConceptScore W2034785972C2777003273 @default.
• W2034785972 hasConceptScore W2034785972C2777658017 @default.
• W2034785972 hasConceptScore W2034785972C2778024521 @default.
• W2034785972 hasConceptScore W2034785972C2779306644 @default.
• W2034785972 hasConceptScore W2034785972C2780352252 @default.
• W2034785972 hasConceptScore W2034785972C2780546910 @default.
• W2034785972 hasConceptScore W2034785972C2781309135 @default.
• W2034785972 hasConceptScore W2034785972C55493867 @default.
• W2034785972 hasConceptScore W2034785972C71315377 @default.
• W2034785972 hasConceptScore W2034785972C71924100 @default.
• W2034785972 hasConceptScore W2034785972C79381400 @default.
• W2034785972 hasConceptScore W2034785972C81439078 @default.
• W2034785972 hasConceptScore W2034785972C86803240 @default.
• W2034785972 hasLocation W20347859721 @default.
• W2034785972 hasLocation W20347859722 @default.
• W2034785972 hasOpenAccess W2034785972 @default.
• W2034785972 hasPrimaryLocation W20347859721 @default.
• W2034785972 hasRelatedWork W1891178476 @default.
• W2034785972 hasRelatedWork W1992073015 @default.
• W2034785972 hasRelatedWork W1996440026 @default.
• W2034785972 hasRelatedWork W2004529111 @default.
• W2034785972 hasRelatedWork W2016421149 @default.
• W2034785972 hasRelatedWork W2044253962 @default.
• W2034785972 hasRelatedWork W2067973425 @default.
• W2034785972 hasRelatedWork W2143991348 @default.
• W2034785972 hasRelatedWork W2156554178 @default.
• W2034785972 hasRelatedWork W2508431854 @default.

• next