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- W2034787232 abstract "SummaryPregnant rats were given single injections of nicotinamide (NAM) (8-100 mg/kg body wt) before or after a teratogenic dose of the vitamin antimetabolite 6-amino-nicotinamide (6-AN) late in gestation. NAM effectively competed with 6-AN in preventing cleft palate when given 2 hours before, simultaneously, or up to 2 hours after antimetabolite treatment. However, vitamin replacement therapy was unable to prevent palatal abnormalities or restrict the action of 6-AN to specific time periods when given 12-24 hours before or 2-72 hours after 6-AN administration." @default.
- W2034787232 created "2016-06-24" @default.
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- W2034787232 date "1967-03-01" @default.
- W2034787232 modified "2023-09-26" @default.
- W2034787232 title "Effects of Acute Vitamin Replacement Therapy on 6-aminonicotin-amide Induced Cleft Palate Late in Rat Pregnancy." @default.
- W2034787232 doi "https://doi.org/10.3181/00379727-124-31878" @default.
- W2034787232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4225749" @default.
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