FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034787434> ?p ?o ?g. }

• W2034787434 endingPage "e28320" @default.
• W2034787434 startingPage "e28320" @default.
• W2034787434 abstract "Highly parallel analysis of gene expression has recently been used to identify gene sets or 'signatures' to improve patient diagnosis and risk stratification. Once a signature is generated, traditional statistical testing is used to evaluate its prognostic performance. However, due to the dimensionality of microarrays, this can lead to false interpretation of these signatures.A method was developed to test batches of a user-specified number of randomly chosen signatures in patient microarray datasets. The percentage of random generated signatures yielding prognostic value was assessed using ROC analysis by calculating the area under the curve (AUC) in six public available cancer patient microarray datasets. We found that a signature consisting of randomly selected genes has an average 10% chance of reaching significance when assessed in a single dataset, but can range from 1% to ∼40% depending on the dataset in question. Increasing the number of validation datasets markedly reduces this number.We have shown that the use of an arbitrary cut-off value for evaluation of signature significance is not suitable for this type of research, but should be defined for each dataset separately. Our method can be used to establish and evaluate signature performance of any derived gene signature in a dataset by comparing its performance to thousands of randomly generated signatures. It will be of most interest for cases where few data are available and testing in multiple datasets is limited." @default.
• W2034787434 created "2016-06-24" @default.
• W2034787434 creator A5009208948 @default.
• W2034787434 creator A5033385547 @default.
• W2034787434 creator A5058987737 @default.
• W2034787434 creator A5062158252 @default.
• W2034787434 creator A5070327072 @default.
• W2034787434 date "2011-12-07" @default.
• W2034787434 modified "2023-10-16" @default.
• W2034787434 title "A Simple but Highly Effective Approach to Evaluate the Prognostic Performance of Gene Expression Signatures" @default.
• W2034787434 cites W1607267312 @default.
• W2034787434 cites W1976564639 @default.
• W2034787434 cites W1979483425 @default.
• W2034787434 cites W1983015752 @default.
• W2034787434 cites W1996647803 @default.
• W2034787434 cites W2009255619 @default.
• W2034787434 cites W2061367679 @default.
• W2034787434 cites W2067931814 @default.
• W2034787434 cites W2071143412 @default.
• W2034787434 cites W2074465378 @default.
• W2034787434 cites W2081004609 @default.
• W2034787434 cites W2081524363 @default.
• W2034787434 cites W2088085204 @default.
• W2034787434 cites W2091947792 @default.
• W2034787434 cites W2093909277 @default.
• W2034787434 cites W2104074461 @default.
• W2034787434 cites W2107986563 @default.
• W2034787434 cites W2109103446 @default.
• W2034787434 cites W2115157373 @default.
• W2034787434 cites W2137525633 @default.
• W2034787434 cites W2150688669 @default.
• W2034787434 cites W2151990594 @default.
• W2034787434 cites W2156711378 @default.
• W2034787434 cites W2157132621 @default.
• W2034787434 cites W2160450758 @default.
• W2034787434 cites W2170140374 @default.
• W2034787434 cites W2171083320 @default.
• W2034787434 cites W4245024447 @default.
• W2034787434 cites W4291237095 @default.
• W2034787434 doi "https://doi.org/10.1371/journal.pone.0028320" @default.
• W2034787434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3233554" @default.
• W2034787434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22163293" @default.
• W2034787434 hasPublicationYear "2011" @default.
• W2034787434 type Work @default.
• W2034787434 sameAs 2034787434 @default.
• W2034787434 citedByCount "19" @default.
• W2034787434 countsByYear W20347874342012 @default.
• W2034787434 countsByYear W20347874342013 @default.
• W2034787434 countsByYear W20347874342014 @default.
• W2034787434 countsByYear W20347874342015 @default.
• W2034787434 countsByYear W20347874342016 @default.
• W2034787434 countsByYear W20347874342017 @default.
• W2034787434 countsByYear W20347874342018 @default.
• W2034787434 countsByYear W20347874342020 @default.
• W2034787434 crossrefType "journal-article" @default.
• W2034787434 hasAuthorship W2034787434A5009208948 @default.
• W2034787434 hasAuthorship W2034787434A5033385547 @default.
• W2034787434 hasAuthorship W2034787434A5058987737 @default.
• W2034787434 hasAuthorship W2034787434A5062158252 @default.
• W2034787434 hasAuthorship W2034787434A5070327072 @default.
• W2034787434 hasBestOaLocation W20347874341 @default.
• W2034787434 hasConcept C104317684 @default.
• W2034787434 hasConcept C105795698 @default.
• W2034787434 hasConcept C111030470 @default.
• W2034787434 hasConcept C119857082 @default.
• W2034787434 hasConcept C121332964 @default.
• W2034787434 hasConcept C124101348 @default.
• W2034787434 hasConcept C150194340 @default.
• W2034787434 hasConcept C153180895 @default.
• W2034787434 hasConcept C154945302 @default.
• W2034787434 hasConcept C183905921 @default.
• W2034787434 hasConcept C18431079 @default.
• W2034787434 hasConcept C186836561 @default.
• W2034787434 hasConcept C2524010 @default.
• W2034787434 hasConcept C2778217198 @default.
• W2034787434 hasConcept C2779696439 @default.
• W2034787434 hasConcept C2779733811 @default.
• W2034787434 hasConcept C33923547 @default.
• W2034787434 hasConcept C41008148 @default.
• W2034787434 hasConcept C54355233 @default.
• W2034787434 hasConcept C58471807 @default.
• W2034787434 hasConcept C60644358 @default.
• W2034787434 hasConcept C62520636 @default.
• W2034787434 hasConcept C70721500 @default.
• W2034787434 hasConcept C8415881 @default.
• W2034787434 hasConcept C86803240 @default.
• W2034787434 hasConcept C95371953 @default.
• W2034787434 hasConceptScore W2034787434C104317684 @default.
• W2034787434 hasConceptScore W2034787434C105795698 @default.
• W2034787434 hasConceptScore W2034787434C111030470 @default.
• W2034787434 hasConceptScore W2034787434C119857082 @default.
• W2034787434 hasConceptScore W2034787434C121332964 @default.
• W2034787434 hasConceptScore W2034787434C124101348 @default.
• W2034787434 hasConceptScore W2034787434C150194340 @default.
• W2034787434 hasConceptScore W2034787434C153180895 @default.
• W2034787434 hasConceptScore W2034787434C154945302 @default.
• W2034787434 hasConceptScore W2034787434C183905921 @default.
• W2034787434 hasConceptScore W2034787434C18431079 @default.

• next