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- W2034787767 abstract "Abstract The pharmacokinetics of oxycodone hydrochloride were investigated following a single 10 mg buccal dose administered to nine healthy volunteers. Plasma samples were collected up to 24 h after administration and analyzed by an original, sensitive and specific selected ion monitoring (SIM) gas chromatography/mass spectrometry (GC-MS) assay, after purification with a solid-phase extraction procedure. The limit of quantitation was 1 ng/ml using a 1 ml plasma sample. The AUC 0–∞ and the C max data of oxycodone hydrochloride were similar to the values reported in the literature for conventional oral tablets. The t max data obtained seem greater for the buccoadhesive disks compared with other oral dosage forms. Mucoadhesion, mucosal irritation and comfort were assessed. No serious problems were encountered. The administration of the new dosage form to cancer patients produced effective pain control, allowing a reduction in the dosing frequency." @default.
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- W2034787767 date "1997-09-01" @default.
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- W2034787767 title "Buccoadhesive oxycodone hydrochloride disks: plasma pharmacokinetics in healthy volunteers and clinical study" @default.
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- W2034787767 doi "https://doi.org/10.1016/s0939-6411(97)00081-7" @default.
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