FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034787803> ?p ?o ?g. }

• W2034787803 endingPage "614" @default.
• W2034787803 startingPage "607" @default.
• W2034787803 abstract "Epilepsy is one of the most important neurological diseases. It concerns about 1% of the population worldwide. Despite the discovery of new molecules, one third of epileptic patients are resistant to anti-epileptic drugs and among them only a few can benefit from resective surgery. In this context, radiotherapy is an interesting alternative to the other treatments and several clinical devices exist (e.g., Gamma Knife(®)). The European Synchrotron Radiation Facility offers the possibility to develop new methods of radiosurgery and to study their antiepileptic effects. Here, we discuss several studies that we performed recently to test and try to understand the antiepileptic effects of X-ray synchrotron microbeams in different animal models of epilepsy. We showed a decrease of seizures after Interlaced Microbeam Radiotherapy (IntMRT) of the somatosensory cortex, known as the seizure generator, in a genetic model of absence epilepsy. These antiepileptic effects were stable over 4 months and with low tissular and functional side-effects. The irradiated pyramidal neurons still displayed their physiological activity but did not synchronize anymore. We also obtained a lasting suppression of seizures after IntMRT of the dorsal hippocampus in a mouse model of mesiotemporal lobe epilepsy. However, an important variability of antiepileptic efficiency was observed probably due to the small size of the targeted structure. Despite these encouraging proofs-of-concepts, there is now a need to adapt IntMRT to other models of epilepsy in rodents which are close to refractory forms of epilepsy in human patients and to implement this approach to non-human primates, before moving to clinical trials." @default.
• W2034787803 created "2016-06-24" @default.
• W2034787803 creator A5001484083 @default.
• W2034787803 creator A5017713438 @default.
• W2034787803 creator A5022693264 @default.
• W2034787803 creator A5025170709 @default.
• W2034787803 creator A5031060590 @default.
• W2034787803 creator A5047317566 @default.
• W2034787803 creator A5048449652 @default.
• W2034787803 creator A5051188519 @default.
• W2034787803 creator A5063116305 @default.
• W2034787803 creator A5090312464 @default.
• W2034787803 date "2015-09-01" @default.
• W2034787803 modified "2023-10-16" @default.
• W2034787803 title "Synchrotron X-ray microbeams: A promising tool for drug-resistant epilepsy treatment" @default.
• W2034787803 cites W1509524576 @default.
• W2034787803 cites W1525931417 @default.
• W2034787803 cites W1932830971 @default.
• W2034787803 cites W1969925610 @default.
• W2034787803 cites W1970064526 @default.
• W2034787803 cites W1971073213 @default.
• W2034787803 cites W1974809694 @default.
• W2034787803 cites W1975181723 @default.
• W2034787803 cites W1989417969 @default.
• W2034787803 cites W1995534033 @default.
• W2034787803 cites W2003385669 @default.
• W2034787803 cites W2009957447 @default.
• W2034787803 cites W2028172015 @default.
• W2034787803 cites W2030399931 @default.
• W2034787803 cites W2031498702 @default.
• W2034787803 cites W2033910757 @default.
• W2034787803 cites W2034952028 @default.
• W2034787803 cites W2037744646 @default.
• W2034787803 cites W2052931950 @default.
• W2034787803 cites W2053321740 @default.
• W2034787803 cites W2057281409 @default.
• W2034787803 cites W2062767419 @default.
• W2034787803 cites W2063464796 @default.
• W2034787803 cites W2063630341 @default.
• W2034787803 cites W2068057789 @default.
• W2034787803 cites W2072269015 @default.
• W2034787803 cites W2075020233 @default.
• W2034787803 cites W2075459457 @default.
• W2034787803 cites W2076259133 @default.
• W2034787803 cites W2079418846 @default.
• W2034787803 cites W2081752203 @default.
• W2034787803 cites W2084257045 @default.
• W2034787803 cites W2089513832 @default.
• W2034787803 cites W2098303658 @default.
• W2034787803 cites W2102658768 @default.
• W2034787803 cites W2106532696 @default.
• W2034787803 cites W2118484564 @default.
• W2034787803 cites W2119959527 @default.
• W2034787803 cites W2123212464 @default.
• W2034787803 cites W2123843070 @default.
• W2034787803 cites W2128325250 @default.
• W2034787803 cites W2146890278 @default.
• W2034787803 cites W2152585732 @default.
• W2034787803 cites W2153757245 @default.
• W2034787803 cites W2299164220 @default.
• W2034787803 cites W2317495993 @default.
• W2034787803 cites W4246817163 @default.
• W2034787803 cites W4247206389 @default.
• W2034787803 cites W4252035275 @default.
• W2034787803 doi "https://doi.org/10.1016/j.ejmp.2015.04.005" @default.
• W2034787803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25934524" @default.
• W2034787803 hasPublicationYear "2015" @default.
• W2034787803 type Work @default.
• W2034787803 sameAs 2034787803 @default.
• W2034787803 citedByCount "18" @default.
• W2034787803 countsByYear W20347878032015 @default.
• W2034787803 countsByYear W20347878032016 @default.
• W2034787803 countsByYear W20347878032017 @default.
• W2034787803 countsByYear W20347878032018 @default.
• W2034787803 countsByYear W20347878032019 @default.
• W2034787803 countsByYear W20347878032020 @default.
• W2034787803 countsByYear W20347878032021 @default.
• W2034787803 countsByYear W20347878032022 @default.
• W2034787803 countsByYear W20347878032023 @default.
• W2034787803 crossrefType "journal-article" @default.
• W2034787803 hasAuthorship W2034787803A5001484083 @default.
• W2034787803 hasAuthorship W2034787803A5017713438 @default.
• W2034787803 hasAuthorship W2034787803A5022693264 @default.
• W2034787803 hasAuthorship W2034787803A5025170709 @default.
• W2034787803 hasAuthorship W2034787803A5031060590 @default.
• W2034787803 hasAuthorship W2034787803A5047317566 @default.
• W2034787803 hasAuthorship W2034787803A5048449652 @default.
• W2034787803 hasAuthorship W2034787803A5051188519 @default.
• W2034787803 hasAuthorship W2034787803A5063116305 @default.
• W2034787803 hasAuthorship W2034787803A5090312464 @default.
• W2034787803 hasBestOaLocation W20347878031 @default.
• W2034787803 hasConcept C151730666 @default.
• W2034787803 hasConcept C15744967 @default.
• W2034787803 hasConcept C169760540 @default.
• W2034787803 hasConcept C2778186239 @default.
• W2034787803 hasConcept C2779343474 @default.
• W2034787803 hasConcept C2780803581 @default.
• W2034787803 hasConcept C2781099131 @default.

• next