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• W2034787988 abstract "Encephalopathy associated with term birth is, fortunately, infrequent (about 2 per 1000 births), and some of these term infants benefit from hypothermia. Very little is known about encephalopathy following preterm birth, and these preterm infants were specifically excluded from hypothermia trials. Chalak et al report a single-center experience from Parkland Memorial Hospital in Dallas, where all deliveries have acid base status evaluated using cord blood samples. The authors found that 2.9% of 1305 infants born at 33 to 35 weeks gestational age had significant perinatal acidosis, and 27% of infants with acidosis also had encephalopathy (using the same criteria applied to term infants for the hypothermic trials). The incidence of encephalopathy was about 7 per 1000 for this high risk delivery service, suggesting that the incidence may be increased in this late preterm population. The good news is that the criteria used for identification of hypothermia in term infants should be applicable for this preterm population. The magnetic resonance imaging evaluations of these infants with encephalopathy support this conclusion. The next step will be to decide if a trial of hypothermia is feasible for the late preterm population.Article page 388▶ Encephalopathy associated with term birth is, fortunately, infrequent (about 2 per 1000 births), and some of these term infants benefit from hypothermia. Very little is known about encephalopathy following preterm birth, and these preterm infants were specifically excluded from hypothermia trials. Chalak et al report a single-center experience from Parkland Memorial Hospital in Dallas, where all deliveries have acid base status evaluated using cord blood samples. The authors found that 2.9% of 1305 infants born at 33 to 35 weeks gestational age had significant perinatal acidosis, and 27% of infants with acidosis also had encephalopathy (using the same criteria applied to term infants for the hypothermic trials). The incidence of encephalopathy was about 7 per 1000 for this high risk delivery service, suggesting that the incidence may be increased in this late preterm population. The good news is that the criteria used for identification of hypothermia in term infants should be applicable for this preterm population. The magnetic resonance imaging evaluations of these infants with encephalopathy support this conclusion. The next step will be to decide if a trial of hypothermia is feasible for the late preterm population. Article page 388▶ Perinatal Acidosis and Hypoxic-Ischemic Encephalopathy in Preterm Infants of 33 to 35 Weeks’ GestationThe Journal of PediatricsVol. 160Issue 3PreviewTo determine the frequency of hypoxic-ischemic encephalopathy (HIE) in preterm infants of 33 to 35 weeks’ gestational age on the basis of physiological screening for perinatal acidosis and neurological assessment of encephalopathy and to correlate neurodevelopmental outcomes with brain magnetic resonance imaging findings. Full-Text PDF" @default.
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• W2034787988 date "2012-03-01" @default.
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• W2034787988 title "Late preterm infants and encephalopathy" @default.
• W2034787988 doi "https://doi.org/10.1016/j.jpeds.2012.01.023" @default.
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